Index: head/archivers/py-xopen/Makefile
===================================================================
--- head/archivers/py-xopen/Makefile	(revision 567502)
+++ head/archivers/py-xopen/Makefile	(revision 567503)
@@ -1,28 +1,28 @@
 # $FreeBSD$
 
 PORTNAME=	xopen
-DISTVERSION=	1.0.0	# py-cutadapt requires 1.0.x
+DISTVERSION=	1.1.0	# py-cutadapt 3.3 requires 1.1.x
 CATEGORIES=	archivers python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	jwb@FreeBSD.org
 COMMENT=	Open compressed files transparently
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools_scm>=0:devel/py-setuptools_scm@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}bz2file>=0.98:archivers/py-bz2file@${PY_FLAVOR} \
 		pigz>=0:archivers/pigz
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pytest>0:devel/py-pytest@${PY_FLAVOR}
 
 USES=		python:3.6+
 USE_PYTHON=	autoplist distutils
 
 NO_ARCH=	yes
 
 do-test:
 	@cd ${WRKSRC} && ${PYTHON_CMD} -m pytest
 
 .include <bsd.port.mk>
Index: head/archivers/py-xopen/distinfo
===================================================================
--- head/archivers/py-xopen/distinfo	(revision 567502)
+++ head/archivers/py-xopen/distinfo	(revision 567503)
@@ -1,3 +1,3 @@
-TIMESTAMP = 1612290513
-SHA256 (xopen-1.0.0.tar.gz) = 2fd9f537d96c6fb2f0bfed2c5ea133d8961dcef0baa3d8c388cb8bea2af5b090
-SIZE (xopen-1.0.0.tar.gz) = 17487
+TIMESTAMP = 1615045123
+SHA256 (xopen-1.1.0.tar.gz) = 38277eb96313b2e8822e19e793791801a1f41bf13ee5b48616a97afc65e9adb3
+SIZE (xopen-1.1.0.tar.gz) = 17836
Index: head/biology/py-cutadapt/Makefile
===================================================================
--- head/biology/py-cutadapt/Makefile	(revision 567502)
+++ head/biology/py-cutadapt/Makefile	(revision 567503)
@@ -1,30 +1,30 @@
 # $FreeBSD$
 
 PORTNAME=	cutadapt
-DISTVERSION=	3.2
+DISTVERSION=	3.3
 CATEGORIES=	biology python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	jwb@FreeBSD.org
 COMMENT=	Trim adapters from high-throughput sequencing reads
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools_scm>0:devel/py-setuptools_scm@${PY_FLAVOR}
-RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}xopen==1.0:archivers/py-xopen@${PY_FLAVOR} \
+RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}xopen==1.1:biology/py-xopen@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}dnaio==0.5:biology/py-dnaio@${PY_FLAVOR}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pytest>0:devel/py-pytest@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytest-timeout>0:devel/py-pytest-timeout@${PY_FLAVOR}
 
 USES=		python:3.6+
 USE_PYTHON=	autoplist concurrent cython distutils
 
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/cutadapt/*.so
 
 do-test:
 	@cd ${WRKSRC} && ${PYTHON_CMD} -m pytest
 
 .include <bsd.port.mk>
Index: head/biology/py-cutadapt/distinfo
===================================================================
--- head/biology/py-cutadapt/distinfo	(revision 567502)
+++ head/biology/py-cutadapt/distinfo	(revision 567503)
@@ -1,3 +1,3 @@
-TIMESTAMP = 1612289840
-SHA256 (cutadapt-3.2.tar.gz) = 82c063129d0449d3c0bfb9b849db2bee6b226d3d1c31cad68011e2473791dc75
-SIZE (cutadapt-3.2.tar.gz) = 292702
+TIMESTAMP = 1615045047
+SHA256 (cutadapt-3.3.tar.gz) = cf502bd0df120d584524ea0e834b45135233c38089e900bd41c3d5cd41ee6eea
+SIZE (cutadapt-3.3.tar.gz) = 294579