Index: head/biology/ncbi-cxx-toolkit/Makefile
===================================================================
--- head/biology/ncbi-cxx-toolkit/Makefile	(revision 549991)
+++ head/biology/ncbi-cxx-toolkit/Makefile	(revision 549992)
@@ -1,32 +1,39 @@
 # $FreeBSD$
 
 PORTNAME=	ncbi-cxx-toolkit
-DISTVERSION=	21_0_0
-PORTREVISION=	2
+DISTVERSION=	22_0_0
 CATEGORIES=	biology science devel
-MASTER_SITES=	ftp://ftp.ncbi.nih.gov/toolbox/ncbi_tools++/2018/Apr_2_2018/
+MASTER_SITES=	ftp://ftp.ncbi.nih.gov/toolbox/ncbi_tools++/2019/Mar_28_2019/
 DISTNAME=	ncbi_cxx--${DISTVERSION}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	NCBI C++ Toolkit
 
 LICENSE=	PD
 LICENSE_FILE=	${WRKSRC}/doc/public/LICENSE
 
-LIB_DEPENDS=	libpcre.so:devel/pcre
+LIB_DEPENDS=	liblmdb.so:databases/lmdb \
+		libpcre.so:devel/pcre
 RUN_DEPENDS=	bash:shells/bash
 
 USES=		compiler:c++11-lang gmake mysql perl5 python shebangfix ssl xorg
 SHEBANG_FILES=	src/app/blast/get_species_taxids.sh src/app/blast/legacy_blast.pl src/app/blast/update_blastdb.pl src/app/winmasker/windowmasker_2.2.22_adapter.py
 USE_XORG=	x11 xpm
 
 GNU_CONFIGURE=	yes
 CONFIGURE_ARGS=	--without-debug --with-dll --without-static
 
-post-install: # autoplist: thousands of files
-	@${STRIP_CMD} ${STAGEDIR}${PREFIX}/bin/run_with_lock
+post-install:
+	# strip
+	@${FIND} ${STAGEDIR}${PREFIX}/bin -type f | ${GREP} -v -E '\.(sh|py|pl)$$' | ${XARGS} ${STRIP_CMD}
+	@${FIND} ${STAGEDIR}${PREFIX}/lib -name "*.so" | ${XARGS} ${STRIP_CMD}
+	# remove an empty directory
+	@${RMDIR} ${STAGEDIR}${PREFIX}/include/ncbi-tools++/objtools/data_loaders/genbank/psg
+	# remove the conflicting file
+	@${RM} ${STAGEDIR}${PREFIX}/lib/liblmdb.so
+	# autoplist: thousands of files
 	@cd ${STAGEDIR}${PREFIX} && \
 		${RMDIR} include/ncbi-tools++/algo/blast/bl2api include/ncbi-tools++/objtools/test && \
 		${FIND} * -type f -or -type l >> ${TMPPLIST}
 
 .include <bsd.port.mk>
Index: head/biology/ncbi-cxx-toolkit/distinfo
===================================================================
--- head/biology/ncbi-cxx-toolkit/distinfo	(revision 549991)
+++ head/biology/ncbi-cxx-toolkit/distinfo	(revision 549992)
@@ -1,3 +1,3 @@
-TIMESTAMP = 1538937167
-SHA256 (ncbi_cxx--21_0_0.tar.gz) = 48cc3ae24ca63d1ab1be148e7525e8c5b9f4eaa5eb36d172800784b640a84a4f
-SIZE (ncbi_cxx--21_0_0.tar.gz) = 52661343
+TIMESTAMP = 1600993142
+SHA256 (ncbi_cxx--22_0_0.tar.gz) = ef39429bbc7f13c44c0d327432d9cfb430f9f20d10d825e6b2c4ddd7ccce457f
+SIZE (ncbi_cxx--22_0_0.tar.gz) = 56042079
Index: head/biology/ncbi-cxx-toolkit/pkg-descr
===================================================================
--- head/biology/ncbi-cxx-toolkit/pkg-descr	(revision 549991)
+++ head/biology/ncbi-cxx-toolkit/pkg-descr	(revision 549992)
@@ -1,24 +1,24 @@
 NCBI C++ Toolkit provides free, portable, public domain libraries with no
 restrictions use. It has been written in the National Center for Biotechnology
 Information in Bethesda, MD.
 
 It is vaguely a successor, or a new generation of biology/ncbi-toolkit.
 
 It contains:
 * Networking and Interprocess Communication (IPC) library
 * MultiThreading Library
 * CGI and Fast-CGI Library, HTML Generation Library
 * SQL Database Access Library, C++ wrapper library for BerkeleyDB
 * C++ IOSTREAM Adaptor/Wrapper Library
 * GZIP and BZ2 C++ Wrapper Library with IOSTREAM adaptors
 * ASN.1 and XML Serialization Library with C++ Code Generator Tool (datatool)
 * Date and Time Library
 * File System Function Library
 * Command-Line Argument, Configuration and Environment Processing Library
 * Sequence Alignment Algorithms Library
 * BLAST Engine Library
 * Biological Sequences Retrieval and Processing Library
 * Portable FLTK and OpenGL based GUI and graphic libraries
 * XmlWrapp (XML parsing and handling, XSLT, XPath)
 
-WWW: https://www.ncbi.nlm.nih.gov/IEB/ToolBox/CPP_DOC/
+WWW: https://ncbi.github.io/cxx-toolkit/