diff --git a/databases/py-mysqlclient/Makefile b/databases/py-mysqlclient/Makefile
index 70a85c7a0132..0e89dd503d4d 100644
--- a/databases/py-mysqlclient/Makefile
+++ b/databases/py-mysqlclient/Makefile
@@ -1,30 +1,30 @@
 PORTNAME=	mysqlclient
-DISTVERSION=	2.2.0
+DISTVERSION=	2.2.1
 CATEGORIES=	databases python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	fluffy@FreeBSD.org
 COMMENT=	MySQL database connector for Python
 WWW=		https://pypi.org/project/mysqlclient
 
 LICENSE=	GPLv2
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PY_SETUPTOOLS} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0.37:devel/py-wheel@${PY_FLAVOR}
 
 USES=		compiler:c11 dos2unix iconv mysql pkgconfig python ssl
 USE_PYTHON=	autoplist concurrent pep517
 
 PORTDOCS=	*
 
 CONFLICTS=	py*-MySQLdb py*-MySQLdb5[0-9] py*-MySQLdb
 
 OPTIONS_DEFINE=		DOCS
 
 post-install-DOCS-on:
 	@${MKDIR} ${STAGEDIR}${DOCSDIR}
 	${INSTALL_DATA} ${WRKSRC}/README.md ${WRKSRC}/doc/* ${STAGEDIR}${DOCSDIR}
 
 .include <bsd.port.mk>
diff --git a/databases/py-mysqlclient/distinfo b/databases/py-mysqlclient/distinfo
index 31827594e35a..62d1cf5eb845 100644
--- a/databases/py-mysqlclient/distinfo
+++ b/databases/py-mysqlclient/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1687512745
-SHA256 (mysqlclient-2.2.0.tar.gz) = 04368445f9c487d8abb7a878e3d23e923e6072c04a6c320f9e0dc8a82efba14e
-SIZE (mysqlclient-2.2.0.tar.gz) = 89543
+TIMESTAMP = 1703603120
+SHA256 (mysqlclient-2.2.1.tar.gz) = 2c7ad15b87293b12fd44b47c46879ec95ec647f4567e866ccd70b8337584e9b2
+SIZE (mysqlclient-2.2.1.tar.gz) = 89966
diff --git a/databases/py-mysqlclient/files/patch-setup.py b/databases/py-mysqlclient/files/patch-setup.py
deleted file mode 100644
index 4bb4df91be54..000000000000
--- a/databases/py-mysqlclient/files/patch-setup.py
+++ /dev/null
@@ -1,11 +0,0 @@
---- setup.py
-+++ setup.py
-@@ -14,7 +14,7 @@
- 
- def find_package_name():
-     """Get available pkg-config package name"""
--    packages = ["mysqlclient", "mariadb"]
-+    packages = ["mysqlclient", "mariadb", "libmariadb"]
-     for pkg in packages:
-         try:
-             cmd = f"pkg-config --exists {pkg}"