diff --git a/biology/mashmap/Makefile b/biology/mashmap/Makefile
index d9dc5f5fafa4..b1be9f3f6461 100644
--- a/biology/mashmap/Makefile
+++ b/biology/mashmap/Makefile
@@ -1,24 +1,31 @@
 PORTNAME=	mashmap
 DISTVERSIONPREFIX=	v
 DISTVERSION=	3.0.6
+PORTREVISION=	1
 CATEGORIES=	biology
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Fast approximate aligner for long DNA sequences
 WWW=		https://github.com/marbl/MashMap
 
 LICENSE=	PD
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
+BROKEN_i386=	compilation fails: fatal error: unknown type name '__uint128_t'
+
 LIB_DEPENDS=	libgsl.so:math/gsl
 
 USES=		cmake compiler:c++17-lang localbase:ldflags
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	marbl
 GH_PROJECT=	MashMap
 
+OPTIONS_DEFINE=		NATIVE
+
+NATIVE_CMAKE_BOOL=	OPTIMIZE_FOR_NATIVE
+
 PLIST_FILES=	bin/mashmap \
 		bin/mashmap-align
 
 .include <bsd.port.mk>