diff --git a/science/rdkit/files/patch-CMakeLists.txt b/science/rdkit/files/patch-CMakeLists.txt
index a4594f30ae57..ae2118c6df4d 100644
--- a/science/rdkit/files/patch-CMakeLists.txt
+++ b/science/rdkit/files/patch-CMakeLists.txt
@@ -1,18 +1,35 @@
---- CMakeLists.txt.orig	2020-06-10 03:59:48 UTC
+--- CMakeLists.txt.orig	2024-12-20 08:56:08 UTC
 +++ CMakeLists.txt
-@@ -432,12 +432,14 @@ if(NOT RDK_INSTALL_INTREE)
+@@ -76,12 +76,12 @@ if(NOT MSVC)
+ 
+ if(NOT MSVC)
+   if(RDK_OPTIMIZE_POPCNT)
+-    if(CMAKE_SYSTEM_PROCESSOR MATCHES "^(aarch64|arm64)")
+-      message("RDK_OPTIMIZE_POPCNT is not available on aarch64 or arm64")
+-    elseif(CMAKE_SYSTEM_PROCESSOR MATCHES "^(ppc64|powerpc64)")
++    if(CMAKE_SYSTEM_PROCESSOR MATCHES "^(ppc64|powerpc64)")
+       set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -mpopcntd")
+-    else()
++    elseif(CMAKE_SYSTEM_PROCESSOR MATCHES "^(i386|amd64|x86_64)")
+       set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -mpopcnt")
++    else()
++      message("RDK_OPTIMIZE_POPCNT is not available on your architecture")
+     endif()
+   endif()
+ endif()
+@@ -516,12 +516,14 @@ if(NOT RDK_INSTALL_INTREE)
        COMPONENT data
        PATTERN ".svn" EXCLUDE
        )
 +  if (FREEBSD_INSTALL_DOCS)
    install(DIRECTORY Docs DESTINATION
 -      ${RDKit_ShareDir}
 +      ${FREEBSD_DOCSDIR}
        COMPONENT docs
        PATTERN ".svn" EXCLUDE
        PATTERN "_build" EXCLUDE
        )
 +  endif()
    install(DIRECTORY Contrib DESTINATION
        ${RDKit_ShareDir}
        COMPONENT extras