diff --git a/biology/py-biopython/Makefile b/biology/py-biopython/Makefile
index ae4b6cdd3648..79986928f550 100644
--- a/biology/py-biopython/Makefile
+++ b/biology/py-biopython/Makefile
@@ -1,33 +1,31 @@
 PORTNAME=	biopython
-DISTVERSION=	1.81
-PORTREVISION=	1
+DISTVERSION=	1.83
 CATEGORIES=	biology python
 MASTER_SITES=	http://www.biopython.org/DIST/
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	mauricio@arareko.net
 COMMENT=	Collection of Python modules for bioinformatics
 WWW=		https://biopython.org/
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.rst
 
 BUILD_DEPENDS=	${PYNUMPY}
 RUN_DEPENDS=	${PYNUMPY}
 
 USES=		python
 USE_PYTHON=	distutils autoplist
 
 OPTIONS_DEFINE=		REPORTLAB
 OPTIONS_DEFAULT=	REPORTLAB
 
 REPORTLAB_DESC=		PDF support in Bio.Graphics module
 REPORTLAB_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}reportlab>0:print/py-reportlab@${PY_FLAVOR}
 
 post-install:
 	@${STRIP_CMD} \
 		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/Bio/*.so \
-		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/Bio/*/*.so \
-		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/Bio/*/*/*.so \
+		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/Bio/*/*.so
 
 .include <bsd.port.mk>
diff --git a/biology/py-biopython/distinfo b/biology/py-biopython/distinfo
index eb6174add02f..96b7a12dd769 100644
--- a/biology/py-biopython/distinfo
+++ b/biology/py-biopython/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1678108052
-SHA256 (biopython-1.81.tar.gz) = 2cf38112b6d8415ad39d6a611988cd11fb5f33eb09346666a87263beba9614e0
-SIZE (biopython-1.81.tar.gz) = 19324875
+TIMESTAMP = 1712540226
+SHA256 (biopython-1.83.tar.gz) = 78e6bfb78de63034037afd35fe77cb6e0a9e5b62706becf78a7d922b16ed83f7
+SIZE (biopython-1.83.tar.gz) = 19431530