diff --git a/biology/py-dnaio/Makefile b/biology/py-dnaio/Makefile
index a292053468f8..a4efca610a3f 100644
--- a/biology/py-dnaio/Makefile
+++ b/biology/py-dnaio/Makefile
@@ -1,19 +1,20 @@
 PORTNAME=	dnaio
-DISTVERSION=	0.5.1	# py-cutadapt 3.3 requires 0.5.x
+DISTVERSION=	1.2.0
 CATEGORIES=	biology python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	jwb@FreeBSD.org
 COMMENT=	Read and write FASTQ and FASTA
 WWW=		https://pypi.python.org/pypi/dnaio
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools_scm>0:devel/py-setuptools_scm@${PY_FLAVOR}
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools_scm>0:devel/py-setuptools_scm@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 
 USES=		python
-USE_PYTHON=	autoplist distutils
+USE_PYTHON=	autoplist cython pep517
 
 .include <bsd.port.mk>
diff --git a/biology/py-dnaio/distinfo b/biology/py-dnaio/distinfo
index b1aa14a78220..26a5cfc997eb 100644
--- a/biology/py-dnaio/distinfo
+++ b/biology/py-dnaio/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1620087008
-SHA256 (dnaio-0.5.1.tar.gz) = c68ecffbf653dfe122f1c10fb8d7c5957ad68acc5c9035c66f81eba1a591d31c
-SIZE (dnaio-0.5.1.tar.gz) = 126820
+TIMESTAMP = 1707060534
+SHA256 (dnaio-1.2.0.tar.gz) = d0528c23516fe4e947970bdef33c423f0a30ab3b083bd4f6f049fd66d8cef803
+SIZE (dnaio-1.2.0.tar.gz) = 58225