diff --git a/biology/hyphy/Makefile b/biology/hyphy/Makefile
index 9e96954a676c..a3720c1b468e 100644
--- a/biology/hyphy/Makefile
+++ b/biology/hyphy/Makefile
@@ -1,29 +1,32 @@
 PORTNAME=	hyphy
 DISTVERSION=	2.5.42
 CATEGORIES=	biology
 
 MAINTAINER=	jrm@FreeBSD.org
 COMMENT=	Hypothesis testing using Phylogenies
 WWW=		https://www.hyphy.org/
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 .if !exists(/usr/include/omp.h)
 BROKEN=		requires OpenMP support that is missing on this architecture
 .endif
 
-ONLY_FOR_ARCHS=	aarch64 amd64 armv7 i386 powerpc64le powerpc64 powerpc
+ONLY_FOR_ARCHS=	aarch64 amd64 armv7 i386 powerpc powerpc64 powerpc64le
 
 LIB_DEPENDS=	libcurl.so:ftp/curl
 
-USES=		cmake localbase:ldflags
+USES=		cmake:insource,testing localbase:ldflags # tests fail in outsource build, see https://github.com/veg/hyphy/issues/1528
+
 USE_GITHUB=	yes
 GH_ACCOUNT=	veg
 
 OPTIONS_DEFINE=	AVX
 AVX_DESC=	Advanced vector extensions support
 
 AVX_CMAKE_OFF=	-DNOAVX:BOOL=ON
 
+# 2 tests fail, see https://github.com/veg/hyphy/issues/1529
+
 .include <bsd.port.mk>