diff --git a/science/py-pymol/Makefile b/science/py-pymol/Makefile
index b31b04de6cb9..73b9bf1ac7bb 100644
--- a/science/py-pymol/Makefile
+++ b/science/py-pymol/Makefile
@@ -1,65 +1,68 @@
 PORTNAME=	pymol
 DISTVERSIONPREFIX=	v
 DISTVERSION=	2.5.0-97
 PORTREVISION=	2
 DISTVERSIONSUFFIX=	-gd24468af
 CATEGORIES=	science biology python
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	OpenGL-based molecular visualization system
 WWW=		https://pymol.org/2/
 
 LICENSE=	PyMOL
 LICENSE_NAME=	Open-Source PyMOL Copyright
 LICENSE_FILE=	${WRKSRC}/LICENSE
 LICENSE_PERMS=	dist-mirror dist-sell pkg-mirror pkg-sell auto-accept
 
+DEPRECATED=	Depends on deprecated devel/py-qt5-pyqt
+EXPIRATION_DATE=	2023-11-28
+
 BUILD_DEPENDS=	${PYNUMPY} \
 		${LOCALBASE}/include/glm/glm.hpp:math/glm \
 		${LOCALBASE}/include/mmtf.hpp:science/mmtf-cpp
 LIB_DEPENDS=	libfreetype.so:print/freetype2 \
 		libpng.so:graphics/png \
 		libmsgpackc.so:devel/msgpack-c \
 		libnetcdf.so:science/netcdf
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}msgpack>0:devel/py-msgpack@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}Pmw>0:x11-toolkits/py-Pmw@${PY_FLAVOR} \
 		${PYNUMPY}
 
 USES=		compiler:c++11-lang gl gnome python tar:bz2
 USE_GL=		gl glew glu glut
 USE_GNOME=	libxml2
 USE_PYTHON=	distutils concurrent # autoplist is broken: https://github.com/schrodinger/pymol-open-source/issues/99
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	schrodinger
 GH_PROJECT=	${PORTNAME}-open-source
 
 CONFLICTS_INSTALL=	${PYTHON_PKGNAMEPREFIX}chempy # chempy port is unrelated, see https://github.com/schrodinger/pymol-open-source/issues/100
 
 CXXFLAGS+=	-DMSGPACK_NO_BOOST # in line with MSGPACK_USE_BOOST=OFF in devel/msgpack-cxx
 
 .if !exists(/usr/include/omp.h)
 PYDISTUTILS_CONFIGUREARGS+=	--use-openmp=no
 PYDISTUTILS_BUILDARGS+=		--use-openmp=no
 .endif
 
 OPTIONS_SINGLE=		GUI
 OPTIONS_SINGLE_GUI=	QT5 TK
 OPTIONS_DEFAULT=	QT5
 
 QT5_USES=		pyqt:5
 QT5_USE=		PYQT=pyqt5:run
 
 post-patch-TK-on:
 	@${REINPLACE_CMD} -e ' \
 		23s|if not PYQT_NAME:|if False:| ; \
 		s|from PyQt5 import|from X import|' \
 		${WRKSRC}/modules/${PORTNAME}/Qt/__init__.py
 
 post-install:
 	@${REINPLACE_CMD} -i '' -e 's|#!/bin/bash|#!/bin/sh|' ${STAGEDIR}${PREFIX}/bin/${PORTNAME}
 	@${STRIP_CMD} ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/${PORTNAME}/_cmd*.so
 	@${STRIP_CMD} ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/chempy/champ/_champ*.so
 
 .include <bsd.port.mk>