diff --git a/biology/bwa/Makefile b/biology/bwa/Makefile
index 13316b89e355..3481077c3af3 100644
--- a/biology/bwa/Makefile
+++ b/biology/bwa/Makefile
@@ -1,35 +1,35 @@
 PORTNAME=	bwa
 DISTVERSIONPREFIX=	v
-DISTVERSION=	0.7.18
+DISTVERSION=	0.7.19
 CATEGORIES=	biology
 
 MAINTAINER=	alster@vinterdalen.se
 COMMENT=	Burrows-Wheeler sequence aligner
 WWW=		https://bio-bwa.sourceforge.net/ \
 		https://sourceforge.net/projects/bio-bwa/ \
 		https://github.com/lh3/bwa/
 
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/COPYING
 
 # Recheck these after 0.7.18 update
 BROKEN_mips=	fails to compile: cc1: unrecognized command line option "-msse2"
 BROKEN_mips64=	fails to compile: cc1: unrecognized command line option "-msse2"
 
 BUILD_DEPENDS=	simde>0:devel/simde
 
 USES=		gmake localbase perl5 shebangfix
 USE_GITHUB=	yes
 GH_ACCOUNT=	lh3
 USE_PERL5=	run
 
 SHEBANG_FILES=	qualfa2fq.pl xa2multi.pl
 
 PLIST_FILES=	bin/bwa bin/qualfa2fq.pl bin/xa2multi.pl share/man/man1/bwa.1.gz
 
 do-install:
 	${INSTALL_PROGRAM} ${WRKSRC}/bwa ${STAGEDIR}${PREFIX}/bin
 	${INSTALL_SCRIPT} ${WRKSRC}/*.pl ${STAGEDIR}${PREFIX}/bin
 	${INSTALL_MAN} ${WRKSRC}/*.1 ${STAGEDIR}${PREFIX}/share/man/man1
 
 .include <bsd.port.mk>
diff --git a/biology/bwa/distinfo b/biology/bwa/distinfo
index b9b0548bf588..d6325d94fb62 100644
--- a/biology/bwa/distinfo
+++ b/biology/bwa/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1732300398
-SHA256 (lh3-bwa-v0.7.18_GH0.tar.gz) = 194788087f7b9a77c0114aa481b2ef21439f6abab72488c83917302e8d0e7870
-SIZE (lh3-bwa-v0.7.18_GH0.tar.gz) = 238036
+TIMESTAMP = 1742771512
+SHA256 (lh3-bwa-v0.7.19_GH0.tar.gz) = cdff5db67652c5b805a3df08c4e813a822c65791913eccfb3cf7d528588f37bc
+SIZE (lh3-bwa-v0.7.19_GH0.tar.gz) = 238518
diff --git a/biology/bwa/files/patch-Makefile b/biology/bwa/files/patch-Makefile
index e7d704d5e0b3..a48f921d7ddf 100644
--- a/biology/bwa/files/patch-Makefile
+++ b/biology/bwa/files/patch-Makefile
@@ -1,11 +1,11 @@
---- Makefile.orig	2014-05-19 13:11:41 UTC
+--- Makefile.orig	2025-03-22 18:55:09 UTC
 +++ Makefile
 @@ -1,6 +1,6 @@
 -CC=			gcc
 +CC?=			gcc
  #CC=			clang --analyze
--CFLAGS=		-g -Wall -Wno-unused-function -O2
-+CFLAGS?=		-g -Wall -Wno-unused-function -O2
+-CFLAGS=		-g -Wall -Wno-unused-function -O3
++CFLAGS?=		-g -Wall -Wno-unused-function -O3
  WRAP_MALLOC=-DUSE_MALLOC_WRAPPERS
  AR=			ar
  DFLAGS=		-DHAVE_PTHREAD $(WRAP_MALLOC)