diff --git a/biology/fermi-lite/Makefile b/biology/fermi-lite/Makefile
index 5a2a8f5817e0..003ba3006bae 100644
--- a/biology/fermi-lite/Makefile
+++ b/biology/fermi-lite/Makefile
@@ -1,44 +1,48 @@
 PORTNAME=	fermi-lite
 DISTVERSIONPREFIX=	v
 DISTVERSION=	0.1-13
 DISTVERSIONSUFFIX=	-g85f159e
 CATEGORIES=	biology devel
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Library and tool for assembling Illumina short reads in small regions
 WWW=		https://github.com/lh3/fermi-lite
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
-ONLY_FOR_ARCHS=		amd64 i386
+ONLY_FOR_ARCHS=		aarch64 amd64 armv7 i386
 ONLY_FOR_ARCHS_REASON=	Use of the <emmintrin.h> header in ksw.c which is only for SSE2
 
-USES=		gmake
+armv7_BUILD_DEPENDS=	${LOCALBASE}/include/sse2neon.h:devel/sse2neon
+aarch64_BUILD_DEPENDS=	${armv7_BUILD_DEPENDS}
+BUILD_DEPENDS+=	${${ARCH}_BUILD_DEPENDS}
+
+USES=		gmake localbase
 USE_LDCONFIG=	yes
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	lh3
 
 CFLAGS_powerpc64le=	-DNO_WARN_X86_INTRINSICS # not sure if it was really ever built on powerpc64le
 CFLAGS_i386=	-msse2
 MAKE_ARGS=	CFLAGS="${CFLAGS}"
 
 BINARY_ALIAS=	gcc=${CC}
 
 PLIST_FILES=	bin/fml-asm \
 		include/fml.h \
 		lib/libfml.a \
 		lib/libfml.so
 
 post-build:
 		@cd ${WRKSRC} && \
 			${CC} ${CFLAGS} -fPIC ${LDFLAGS} -shared $$(ls *.c | grep -v example.c) -o libfml.so
 
 do-install:
 	${INSTALL_PROGRAM} ${WRKSRC}/fml-asm ${STAGEDIR}${PREFIX}/bin
 	${INSTALL_DATA} ${WRKSRC}/fml.h ${STAGEDIR}${PREFIX}/include
 	${INSTALL_DATA} ${WRKSRC}/libfml.a ${STAGEDIR}${PREFIX}/lib
 	${INSTALL_LIB} ${WRKSRC}/libfml.so ${STAGEDIR}${PREFIX}/lib
 
 .include <bsd.port.mk>
diff --git a/biology/fermi-lite/files/patch-ksw.c b/biology/fermi-lite/files/patch-ksw.c
new file mode 100644
index 000000000000..ec5348eedc45
--- /dev/null
+++ b/biology/fermi-lite/files/patch-ksw.c
@@ -0,0 +1,14 @@
+--- ksw.c.orig	2024-10-15 14:34:34 UTC
++++ ksw.c
+@@ -25,7 +25,11 @@
+ 
+ #include <stdlib.h>
+ #include <stdint.h>
++#if defined(__arm__) || defined(__aarch64__)
++#include <sse2neon.h>
++#else
+ #include <emmintrin.h>
++#endif
+ #include "ksw.h"
+ 
+ #ifdef __GNUC__