diff --git a/misc/snakemake/Makefile b/misc/snakemake/Makefile
index d470ebec565d..ccc1748613d5 100644
--- a/misc/snakemake/Makefile
+++ b/misc/snakemake/Makefile
@@ -1,36 +1,36 @@
 PORTNAME=	snakemake
-DISTVERSION=	6.11.1
+DISTVERSION=	6.12.1
 CATEGORIES=	misc python
 MASTER_SITES=	CHEESESHOP
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Workflow management system
 
 LICENSE=	MIT
 
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}appdirs>0:devel/py-appdirs@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}connection_pool>=0.0.3>0:devel/py-connection_pool@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}configargparse>0:devel/py-configargparse@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}datrie>0:devel/py-datrie@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}docutils>0:textproc/py-docutils@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}filelock>0:sysutils/py-filelock@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}gitpython>0:devel/py-gitpython@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}jsonschema>0:devel/py-jsonschema@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}nbformat>0:devel/py-nbformat@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}PuLP>=2.0:math/py-PuLP@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}psutil>0:sysutils/py-psutil@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}ratelimiter>0:devel/py-ratelimiter@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}requests>0:www/py-requests@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}smart-open>=3.0:net/py-smart-open@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}stopit>0:devel/py-stopit@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tabulate>0:devel/py-tabulate@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}toposort>0:devel/py-toposort@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wrapt>0:devel/py-wrapt@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}yaml>0:devel/py-yaml@${PY_FLAVOR}
 
 USES=		python:3.5+
 USE_PYTHON=	distutils noflavors autoplist
 
 NO_ARCH=	yes
 
 .include <bsd.port.mk>
diff --git a/misc/snakemake/distinfo b/misc/snakemake/distinfo
index dc34ad3616a2..5c43995e3c88 100644
--- a/misc/snakemake/distinfo
+++ b/misc/snakemake/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1637960820
-SHA256 (snakemake-6.11.1.tar.gz) = fd99230d5e426dde38b9bc085f3796506185bb79a9c439b5300e662b2d424463
-SIZE (snakemake-6.11.1.tar.gz) = 278039
+TIMESTAMP = 1638513491
+SHA256 (snakemake-6.12.1.tar.gz) = 6bc45e98c0cd90d8e696ff09ad87cddf815baf50bd75964ea01639c9699ca50d
+SIZE (snakemake-6.12.1.tar.gz) = 278675