diff --git a/biology/hyphy/Makefile b/biology/hyphy/Makefile
index 0373fc76233c..536e4130c0db 100644
--- a/biology/hyphy/Makefile
+++ b/biology/hyphy/Makefile
@@ -1,29 +1,29 @@
 PORTNAME=	hyphy
-DISTVERSION=	2.5.49
+DISTVERSION=	2.5.50
 CATEGORIES=	biology
 
 MAINTAINER=	jrm@FreeBSD.org
 COMMENT=	Hypothesis testing using Phylogenies
 WWW=		https://www.hyphy.org/
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 ONLY_FOR_ARCHS=	aarch64 amd64 armv7 i386 powerpc powerpc64 powerpc64le
 
 LIB_DEPENDS=	libcurl.so:ftp/curl
 TEST_DEPENDS=	bash:shells/bash
 
 USES=		cmake:insource,testing localbase:ldflags # tests fail in outsource build, see https://github.com/veg/hyphy/issues/1528
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	veg
 
 OPTIONS_DEFINE=	AVX
 AVX_DESC=	Advanced vector extensions support
 
 AVX_CMAKE_OFF=	-DNOAVX:BOOL=ON
 
 # FEL test is failing. See https://github.com/veg/hyphy/issues/1585
 
 .include <bsd.port.mk>
diff --git a/biology/hyphy/distinfo b/biology/hyphy/distinfo
index 4608f46ed15d..a1978097b5a3 100644
--- a/biology/hyphy/distinfo
+++ b/biology/hyphy/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1679670987
-SHA256 (veg-hyphy-2.5.49_GH0.tar.gz) = 00a30f8b0e8bdc0a6f0a55201082d72cba9f7bd29e1e0e0088a3cedb3dbfeed4
-SIZE (veg-hyphy-2.5.49_GH0.tar.gz) = 5648834
+TIMESTAMP = 1681919231
+SHA256 (veg-hyphy-2.5.50_GH0.tar.gz) = c7597db75275cf017a64719d3134c5a0dca38e04c2e70b9d518f49bbb5f83032
+SIZE (veg-hyphy-2.5.50_GH0.tar.gz) = 5648743