diff --git a/biology/py-pysam/Makefile b/biology/py-pysam/Makefile
index 2b86675e98b7..51bd63e0a6d8 100644
--- a/biology/py-pysam/Makefile
+++ b/biology/py-pysam/Makefile
@@ -1,16 +1,16 @@
 PORTNAME=	pysam
-DISTVERSION=	0.18.0
+DISTVERSION=	0.19.0
 CATEGORIES=	biology python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Python module for reading, manipulating and writing genomic data sets
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/COPYING
 
 USES=		gmake python:3.6-3.9
 USE_PYTHON=	autoplist distutils cython cython_run
 
 .include <bsd.port.mk>
diff --git a/biology/py-pysam/distinfo b/biology/py-pysam/distinfo
index b85394097108..d4ecc4b058b1 100644
--- a/biology/py-pysam/distinfo
+++ b/biology/py-pysam/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1639969328
-SHA256 (pysam-0.18.0.tar.gz) = 1d6d49a0b3c626fae410a93d4c80583a8b5ddaacc9b46a080b250dbcebd30a59
-SIZE (pysam-0.18.0.tar.gz) = 3780010
+TIMESTAMP = 1651080270
+SHA256 (pysam-0.19.0.tar.gz) = dcc052566f9509fd93b2a2664f094a13f016fd60cdd189e05fb4eafa0c89505b
+SIZE (pysam-0.19.0.tar.gz) = 3843661