diff --git a/lang/python310/Makefile b/lang/python310/Makefile
index 3dbf8d5d004e..64aba656d340 100644
--- a/lang/python310/Makefile
+++ b/lang/python310/Makefile
@@ -1,159 +1,163 @@
 # Created by: Kubilay Kocak <koobs@FreeBSD.org>
 
 PORTNAME=	python
 DISTVERSION=	${PYTHON_DISTVERSION}
 CATEGORIES=	lang python
 MASTER_SITES=	PYTHON/ftp/python/${DISTVERSION:C/[a-z].*//}
 PKGNAMESUFFIX=	${PYTHON_SUFFIX}
 DISTNAME=	Python-${DISTVERSION}
 DIST_SUBDIR=	python
 
 MAINTAINER=	python@FreeBSD.org
 COMMENT=	Interpreted object-oriented programming language (beta version)
 
 LICENSE=	PSFL
 
 LIB_DEPENDS=	libffi.so:devel/libffi
 
 USES=		compiler:c11 cpe ncurses pathfix pkgconfig readline \
 		shebangfix ssl tar:xz
 PATHFIX_MAKEFILEIN=	Makefile.pre.in
 USE_LDCONFIG=	yes
 GNU_CONFIGURE=	yes
 python_CMD=	${PREFIX}/bin/python${PYTHON_DISTVERSION:R}
 SHEBANG_FILES=	Lib/*.py Lib/*/*.py Lib/*/*/*.py Lib/*/*/*/*.py
 SHEBANG_FILES+=	Lib/test/ziptestdata/exe_with_z64 \
 		Lib/test/ziptestdata/exe_with_zip \
 		Lib/test/ziptestdata/header.sh
 
 # Duplicate python.mk variables. TODO: Let lang/python?? ports use python.mk bits.
 PYTHON_VER=		${PYTHON_DISTVERSION:R}
 PYTHON_VERSION=		python${PYTHON_VER}
 PYTHON_SUFFIX=		${PYTHON_VER:S/.//g}
 
 DISABLED_EXTENSIONS=	_sqlite3 _tkinter _gdbm
 CONFIGURE_ARGS+=	--enable-shared --without-ensurepip \
 			--with-system-ffi
 CONFIGURE_ENV+=		OPT="" # Null out OPT to respect user CFLAGS and remove optimizations
 
 INSTALL_TARGET=		altinstall						# Don't want cloberring of unprefixed files
 
 TEST_TARGET=		buildbottest
 TEST_ARGS=		TESTOPTS=-j${MAKE_JOBS_NUMBER}
 
 MAKE_ARGS+=		INSTALL_SHARED="${INSTALL_LIB}"				# Strip shared library
 
 SUB_FILES=		pkg-message
 SUB_LIST=		PYTHON_SUFFIX=${PYTHON_SUFFIX}
 
 PLIST_SUB=		ABI=${ABIFLAGS} \
 			XY=${PYTHON_SUFFIX} \
 			XYDOT=${PYTHON_VER} \
 			XYZDOT=${DISTVERSION:C/[a-z].*//} \
 			OSMAJOR=${OSVERSION:C/([0-9]*)[0-9]{5}/\1/}		# For plat-freebsd* in pkg-plist. https://bugs.python.org/issue19554
 
 OPTIONS_DEFINE=		DEBUG IPV6 LIBMPDEC NLS PYMALLOC
 OPTIONS_DEFAULT=	LIBMPDEC PYMALLOC
 OPTIONS_RADIO=		HASH
 OPTIONS_RADIO_HASH=	FNV SIPHASH
 OPTIONS_SUB=		yes
 
 LIBMPDEC_DESC=		Use libmpdec from ports instead of bundled version
 NLS_DESC=		Enable gettext support for the locale module
 PYMALLOC_DESC=		Enable specialized mallocs
 
 HASH_DESC=		Hash Algorithm (PEP-456)
 FNV_DESC=		Modified Fowler-Noll-Vo Algorithm
 SIPHASH_DESC=		SipHash24 Algorithm
 
 FNV_CONFIGURE_ON=	--with-hash-algorithm=fnv
 SIPHASH_CONFIGURE_ON=	--with-hash-algorithm=siphash24
 
 DEBUG_CONFIGURE_WITH=	pydebug
 IPV6_CONFIGURE_ENABLE=	ipv6
 
 LIBMPDEC_CONFIGURE_ON=	--with-system-libmpdec
 LIBMPDEC_LIB_DEPENDS=	libmpdec.so:math/mpdecimal
 
 # Use CPPFLAGS over CFLAGS due to -I ordering, causing elementtree and pyexpat
 # to break in Python 2.7, or preprocessor complaints in Python >= 3.3
 # Upstream Issue: https://bugs.python.org/issue6299
 NLS_USES=		gettext
 NLS_CPPFLAGS=		-I${LOCALBASE}/include
 NLS_LIBS=		-L${LOCALBASE}/lib -lintl
 NLS_CONFIGURE_ENV_OFF=	ac_cv_lib_intl_textdomain=no ac_cv_header_libintl_h=no
 
 PYMALLOC_CONFIGURE_WITH=	pymalloc
 
 .include "${.CURDIR}/Makefile.version"
 .include <bsd.port.options.mk>
 
 .if ${PORT_OPTIONS:MDEBUG}
 ABIFLAGS:=	d${ABIFLAGS}
 .endif
 
 .if !empty(ABIFLAGS)
 PLIST_FILES+=	bin/python${PYTHON_VER}${ABIFLAGS} \
 		bin/python${PYTHON_VER}${ABIFLAGS}-config \
 		libdata/pkgconfig/python-${PYTHON_VER}${ABIFLAGS}.pc \
 		libdata/pkgconfig/python-${PYTHON_VER}${ABIFLAGS}-embed.pc
 .endif
 
 .if ${ARCH} == sparc64
 CFLAGS+=	-DPYTHON_DEFAULT_RECURSION_LIMIT=900
 .endif
 
 # See https://bugs.freebsd.org/115940 and https://bugs.freebsd.org/193650
 .if !exists(/usr/bin/ypcat) || defined(WITHOUT_NIS)
 PLIST_SUB+=	NO_NIS="@comment "
 DISABLED_EXTENSIONS+=	nis
 .else
 PLIST_SUB+=	NO_NIS=""
 .endif
 
 # Python 3.10 requires OpenSSL >= 1.1.1 (PEP 644), so with
 # older OpenSSL or libressl, some modules are not built
 .if ${OPSYS} == FreeBSD && ${OSVERSION} < 1200000 && !${SSL_DEFAULT:Mopenssl*} || ${SSL_DEFAULT:Mlibressl*}
 PLIST_SUB+=	SUPPORTED_OPENSSL="@comment "
 .else
 PLIST_SUB+=	SUPPORTED_OPENSSL=""
 .endif
 
 post-patch:
 # disable the detection of includes and library from e2fsprogs-libuuid,
 # which introduces hidden dependency and breaks build
 	@${REINPLACE_CMD} -e 's|uuid/uuid.h|ignore_&|' ${WRKSRC}/configure
 	@${REINPLACE_CMD} -e '/find_library_file/ s|uuid|ignore_&|' ${WRKSRC}/setup.py
+# disable detection of multiarch as it breaks with clang >= 13, which adds a
+# major.minor version number in -print-multiarch output, confusing Python
+	@${REINPLACE_CMD} -e 's|^MULTIARCH=.*|MULTIARCH=|' ${WRKSRC}/configure \
+		${WRKSRC}/configure.ac
 # Apply DISABLED_EXTENSIONS
 	@${ECHO_CMD} '*disabled*' > ${WRKSRC}/Modules/Setup.local
 .  for _module in ${DISABLED_EXTENSIONS}
 		@${ECHO_CMD} ${_module} >> ${WRKSRC}/Modules/Setup.local
 .  endfor
 
 post-install:
 .if ! ${PORT_OPTIONS:MDEBUG}
 	${RM} ${STAGEDIR}${PREFIX}/lib/libpython3.so						# Upstream Issue: https://bugs.python.org/issue17975
 .endif
 # This code block exists for the qemu-user enabled cross build environment.
 # When using this environment in poudriere, CC is not set to the default
 # of /usr/bin/cc and a cross-compile toolchain is used.  We need to hand
 # edit this so that the run time configuration for python matches what the
 # FreeBSD base system provides.  sbruno 02Aug2017
 .if ${CC} == /nxb-bin/usr/bin/cc
 	@${REINPLACE_CMD} -e 's=/nxb-bin==' \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/_sysconfigdata_${ABIFLAGS}_freebsd${OSREL:R}_.py
 	@cd ${WRKSRC} && ${SETENV} LD_LIBRARY_PATH=${WRKSRC} \
 		./python -E -m compileall -d ${PREFIX}/lib/python${PYTHON_VER} \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/_sysconfigdata_${ABIFLAGS}_freebsd${OSREL:R}_.py
 	@cd ${WRKSRC} && ${SETENV} LD_LIBRARY_PATH=${WRKSRC} \
 		./python -E -O -m compileall -d ${PREFIX}/lib/python${PYTHON_VER} \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/_sysconfigdata_${ABIFLAGS}_freebsd${OSREL:R}_.py
 	@${REINPLACE_CMD} -e 's=/nxb-bin==' \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/config-${PYTHON_VER}${ABIFLAGS}/Makefile
 .endif
 	for i in ${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/lib-dynload/*.so; do \
 		${STRIP_CMD} $$i; done								# Strip shared extensions
 	${INSTALL_DATA} ${WRKSRC}/Tools/gdb/libpython.py \
 		${STAGEDIR}${PREFIX}/lib/libpython${PYTHON_VER}${ABIFLAGS}.so.1.0-gdb.py
 
 .include <bsd.port.mk>
diff --git a/lang/python36/Makefile b/lang/python36/Makefile
index 93aa71936d4d..5b67fbd5044a 100644
--- a/lang/python36/Makefile
+++ b/lang/python36/Makefile
@@ -1,153 +1,159 @@
 # Created by: Kubilay Kocak <koobs@FreeBSD.org>
 
 PORTNAME=	python
 DISTVERSION=	${PYTHON_DISTVERSION}
 CATEGORIES=	lang python
 MASTER_SITES=	PYTHON/ftp/python/${DISTVERSION}
 PKGNAMESUFFIX=	${PYTHON_SUFFIX}
 DISTNAME=	Python-${DISTVERSION}
 DIST_SUBDIR=	python
 
 # Resolve sinpi name clash with libm (IEEE-754 violation)
 PATCH_SITES=	https://github.com/python/cpython/commit/
 PATCHFILES=	f57cd8288dbe6aba99c057f37ad6d58f8db75350.patch:-p1 \
 		f9c01a16dae8aa15d264a1937fb589e8598d1c88.patch:-p1
 
 MAINTAINER=	python@FreeBSD.org
 COMMENT=	Interpreted object-oriented programming language
 
 LICENSE=	PSFL
 
 DEPRECATED=	Upgrade to a newer Python version. 3.6 is in maintenance status and gets security fixes only. End-of-Life: 2021-12-23. See https://devguide.python.org/#status-of-python-branches
 EXPIRATION_DATE=	2021-12-31
 
 USES=		cpe ncurses pathfix pkgconfig readline shebangfix ssl tar:xz
 PATHFIX_MAKEFILEIN=	Makefile.pre.in
 USE_LDCONFIG=	yes
 GNU_CONFIGURE=	yes
 python_CMD=	${PREFIX}/bin/python${PYTHON_DISTVERSION:R}
 SHEBANG_FILES=	Lib/*.py Lib/*/*.py Lib/*/*/*.py Lib/*/*/*/*.py
 
 # Duplicate python.mk variables. TODO: Let lang/python?? ports use python.mk bits.
 PYTHON_VER=		${PYTHON_DISTVERSION:R}
 PYTHON_VERSION=		python${PYTHON_VER}
 PYTHON_SUFFIX=		${PYTHON_VER:S/.//g}
 
 DISABLED_EXTENSIONS=	_sqlite3 _tkinter _gdbm
 CONFIGURE_ARGS+=	--enable-shared --without-ensurepip
 CONFIGURE_ENV+=		OPT="" DISABLED_EXTENSIONS="${DISABLED_EXTENSIONS}"	# Null out OPT to respect user CFLAGS and remove optimizations
 
 INSTALL_TARGET=		altinstall						# Don't want cloberring of unprefixed files
 
 TEST_TARGET=		buildbottest
 TEST_ARGS=		TESTOPTS=-j${MAKE_JOBS_NUMBER}
 
 MAKE_ARGS+=		INSTALL_SHARED="${INSTALL_LIB}"				# Strip shared library
 
 SUB_FILES=		pkg-message
 SUB_LIST=		PYTHON_SUFFIX=${PYTHON_SUFFIX}
 
 PLIST_SUB=		ABI=${ABIFLAGS} \
 			XY=${PYTHON_SUFFIX} \
 			XYDOT=${PYTHON_VER} \
 			XYZDOT=${DISTVERSION} \
 			OSMAJOR=${OSVERSION:C/([0-9]*)[0-9]{5}/\1/}		# For plat-freebsd* in pkg-plist. https://bugs.python.org/issue19554
 
 OPTIONS_DEFINE=		DEBUG IPV6 LIBFFI NLS PYMALLOC THREADS
 OPTIONS_DEFAULT=	LIBFFI PYMALLOC THREADS
 OPTIONS_RADIO=		HASH
 OPTIONS_RADIO_HASH=	FNV SIPHASH
 OPTIONS_SUB=		yes
 
 LIBFFI_DESC=		Use libffi from ports instead of bundled version
 NLS_DESC=		Enable gettext support for the locale module
 PYMALLOC_DESC=		Enable specialized mallocs
 
 HASH_DESC=		Hash Algorithm (PEP-456)
 FNV_DESC=		Modified Fowler-Noll-Vo Algorithm
 SIPHASH_DESC=		SipHash24 Algorithm
 
 FNV_CONFIGURE_ON=	--with-hash-algorithm=fnv
 SIPHASH_CONFIGURE_ON=	--with-hash-algorithm=siphash24
 
 DEBUG_CONFIGURE_WITH=	pydebug
 IPV6_CONFIGURE_ENABLE=	ipv6
 
 LIBFFI_CONFIGURE_ON=	--with-system-ffi
 LIBFFI_LIB_DEPENDS=	libffi.so:devel/libffi
 
 # Use CPPFLAGS over CFLAGS due to -I ordering, causing elementtree and pyexpat
 # to break in Python 2.7, or preprocessor complaints in Python >= 3.3
 # Upstream Issue: https://bugs.python.org/issue6299
 NLS_USES=		gettext
 NLS_CPPFLAGS=		-I${LOCALBASE}/include
 NLS_LIBS=		-L${LOCALBASE}/lib -lintl
 NLS_CONFIGURE_ENV_OFF=	ac_cv_lib_intl_textdomain=no ac_cv_header_libintl_h=no
 
 PYMALLOC_CONFIGURE_WITH=	pymalloc
 
 THREADS_CONFIGURE_WITH=	threads
 THREADS_LDFLAGS=	-lpthread
 
 .include "${.CURDIR}/Makefile.version"
 .include <bsd.port.options.mk>
 
 .if ${PORT_OPTIONS:MPYMALLOC}
 ABIFLAGS:=	m${ABIFLAGS}
 .endif
 
 .if ${PORT_OPTIONS:MDEBUG}
 ABIFLAGS:=	d${ABIFLAGS}
 .endif
 
 .if !empty(ABIFLAGS)
 PLIST_FILES+=	bin/python${PYTHON_VER}${ABIFLAGS} \
 		bin/python${PYTHON_VER}${ABIFLAGS}-config \
 		libdata/pkgconfig/python-${PYTHON_VER}${ABIFLAGS}.pc
 .endif
 
 # https://bugs.python.org/issue22521
 # https://bugs.python.org/issue23042
 .if ${ARCH} == i386 && !${PORT_OPTIONS:MLIBFFI}
 BROKEN=		You must use libffi from ports on i386. Enable the LIBFFI option
 .endif
 
 .if ${ARCH} == sparc64
 CFLAGS+=	-DPYTHON_DEFAULT_RECURSION_LIMIT=900
 .endif
 
 # See https://bugs.freebsd.org/115940 and https://bugs.freebsd.org/193650
 .if !exists(/usr/bin/ypcat) || defined(WITHOUT_NIS)
 PLIST_SUB+=	NO_NIS="@comment "
 DISABLED_EXTENSIONS+=	nis
 .else
 PLIST_SUB+=	NO_NIS=""
 .endif
 
+post-patch:
+# disable detection of multiarch as it breaks with clang >= 13, which adds a
+# major.minor version number in -print-multiarch output, confusing Python
+	@${REINPLACE_CMD} -e 's|^MULTIARCH=.*|MULTIARCH=|' ${WRKSRC}/configure \
+		${WRKSRC}/configure.ac
+
 post-install:
 .if ! ${PORT_OPTIONS:MDEBUG}
 	${RM} ${STAGEDIR}${PREFIX}/lib/libpython3.so						# Upstream Issue: https://bugs.python.org/issue17975
 .endif
 # This code block exists for the qemu-user enabled cross build environment.
 # When using this environment in poudriere, CC is not set to the default
 # of /usr/bin/cc and a cross-compile toolchain is used.  We need to hand
 # edit this so that the run time configuration for python matches what the
 # FreeBSD base system provides.  sbruno 02Aug2017
 .if ${CC} == /nxb-bin/usr/bin/cc
 	@${REINPLACE_CMD} -e 's=/nxb-bin==' \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/_sysconfigdata_m_freebsd${OSREL:R}_.py
 	@cd ${WRKSRC} && ${SETENV} LD_LIBRARY_PATH=${WRKSRC} \
 		./python -E -m compileall -d ${PREFIX}/lib/python${PYTHON_VER} \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/_sysconfigdata_m_freebsd${OSREL:R}_.py
 	@cd ${WRKSRC} && ${SETENV} LD_LIBRARY_PATH=${WRKSRC} \
 		./python -E -O -m compileall -d ${PREFIX}/lib/python${PYTHON_VER} \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/_sysconfigdata_m_freebsd${OSREL:R}_.py
 	@${REINPLACE_CMD} -e 's=/nxb-bin==' \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/config-${PYTHON_VER}m/Makefile
 .endif
 	for i in ${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/lib-dynload/*.so; do \
 		${STRIP_CMD} $$i; done								# Strip shared extensions
 	${INSTALL_DATA} ${WRKSRC}/Tools/gdb/libpython.py \
 		${STAGEDIR}${PREFIX}/lib/libpython${PYTHON_VER}${ABIFLAGS}.so.1.0-gdb.py
 
 .include <bsd.port.mk>
diff --git a/lang/python37/Makefile b/lang/python37/Makefile
index 8909af0dd7ab..4db00e66e9d2 100644
--- a/lang/python37/Makefile
+++ b/lang/python37/Makefile
@@ -1,146 +1,150 @@
 # Created by: Kubilay Kocak <koobs@FreeBSD.org>
 
 PORTNAME=	python
 DISTVERSION=	${PYTHON_DISTVERSION}
 CATEGORIES=	lang python
 MASTER_SITES=	PYTHON/ftp/python/${DISTVERSION}
 PKGNAMESUFFIX=	${PYTHON_SUFFIX}
 DISTNAME=	Python-${DISTVERSION}
 DIST_SUBDIR=	python
 
 MAINTAINER=	python@FreeBSD.org
 COMMENT=	Interpreted object-oriented programming language
 
 LICENSE=	PSFL
 
 LIB_DEPENDS=	libffi.so:devel/libffi \
 		libmpdec.so:math/mpdecimal
 
 USES=		cpe ncurses pathfix pkgconfig readline shebangfix ssl tar:xz
 PATHFIX_MAKEFILEIN=	Makefile.pre.in
 USE_LDCONFIG=	yes
 GNU_CONFIGURE=	yes
 python_CMD=	${PREFIX}/bin/python${PYTHON_DISTVERSION:R}
 SHEBANG_FILES=	Lib/*.py Lib/*/*.py Lib/*/*/*.py Lib/*/*/*/*.py
 
 # Duplicate python.mk variables. TODO: Let lang/python?? ports use python.mk bits.
 PYTHON_VER=		${PYTHON_DISTVERSION:R}
 PYTHON_VERSION=		python${PYTHON_VER}
 PYTHON_SUFFIX=		${PYTHON_VER:S/.//g}
 
 DISABLED_EXTENSIONS=	_sqlite3 _tkinter _gdbm
 CONFIGURE_ARGS+=	--enable-shared --with-system-ffi --with-system-libmpdec --without-ensurepip
 CONFIGURE_ENV+=		OPT="" # Null out OPT to respect user CFLAGS and remove optimizations
 
 INSTALL_TARGET=		altinstall						# Don't want cloberring of unprefixed files
 
 TEST_TARGET=		buildbottest
 TEST_ARGS=		TESTOPTS=-j${MAKE_JOBS_NUMBER}
 
 MAKE_ARGS+=		INSTALL_SHARED="${INSTALL_LIB}"				# Strip shared library
 
 SUB_FILES=		pkg-message
 SUB_LIST=		PYTHON_SUFFIX=${PYTHON_SUFFIX}
 
 PLIST_SUB=		ABI=${ABIFLAGS} \
 			XY=${PYTHON_SUFFIX} \
 			XYDOT=${PYTHON_VER} \
 			XYZDOT=${DISTVERSION} \
 			OSMAJOR=${OSVERSION:C/([0-9]*)[0-9]{5}/\1/}		# For plat-freebsd* in pkg-plist. https://bugs.python.org/issue19554
 
 OPTIONS_DEFINE=		DEBUG IPV6 NLS PYMALLOC
 OPTIONS_DEFAULT=	PYMALLOC
 OPTIONS_RADIO=		HASH
 OPTIONS_RADIO_HASH=	FNV SIPHASH
 OPTIONS_SUB=		yes
 
 NLS_DESC=		Enable gettext support for the locale module
 PYMALLOC_DESC=		Enable specialized mallocs
 
 HASH_DESC=		Hash Algorithm (PEP-456)
 FNV_DESC=		Modified Fowler-Noll-Vo Algorithm
 SIPHASH_DESC=		SipHash24 Algorithm
 
 FNV_CONFIGURE_ON=	--with-hash-algorithm=fnv
 SIPHASH_CONFIGURE_ON=	--with-hash-algorithm=siphash24
 
 DEBUG_CONFIGURE_WITH=	pydebug
 IPV6_CONFIGURE_ENABLE=	ipv6
 
 # Use CPPFLAGS over CFLAGS due to -I ordering, causing elementtree and pyexpat
 # to break in Python 2.7, or preprocessor complaints in Python >= 3.3
 # Upstream Issue: https://bugs.python.org/issue6299
 NLS_USES=		gettext
 NLS_CPPFLAGS=		-I${LOCALBASE}/include
 NLS_LIBS=		-L${LOCALBASE}/lib -lintl
 NLS_CONFIGURE_ENV_OFF=	ac_cv_lib_intl_textdomain=no ac_cv_header_libintl_h=no
 
 PYMALLOC_CONFIGURE_WITH=	pymalloc
 
 .include "${.CURDIR}/Makefile.version"
 .include <bsd.port.options.mk>
 
 .if ${PORT_OPTIONS:MPYMALLOC}
 ABIFLAGS:=	m${ABIFLAGS}
 .endif
 
 .if ${PORT_OPTIONS:MDEBUG}
 ABIFLAGS:=	d${ABIFLAGS}
 .endif
 
 .if !empty(ABIFLAGS)
 PLIST_FILES+=	bin/python${PYTHON_VER}${ABIFLAGS} \
 		bin/python${PYTHON_VER}${ABIFLAGS}-config \
 		libdata/pkgconfig/python-${PYTHON_VER}${ABIFLAGS}.pc
 .endif
 
 .if ${ARCH} == sparc64
 CFLAGS+=	-DPYTHON_DEFAULT_RECURSION_LIMIT=900
 .endif
 
 # See https://bugs.freebsd.org/115940 and https://bugs.freebsd.org/193650
 .if !exists(/usr/bin/ypcat) || defined(WITHOUT_NIS)
 PLIST_SUB+=	NO_NIS="@comment "
 DISABLED_EXTENSIONS+=	nis
 .else
 PLIST_SUB+=	NO_NIS=""
 .endif
 
 post-patch:
 # disable the detection of includes and library from e2fsprogs-libuuid,
 # which introduces hidden dependency and breaks build
 	@${REINPLACE_CMD} -e 's|uuid/uuid.h|ignore_&|' ${WRKSRC}/configure
 	@${REINPLACE_CMD} -e '/find_library_file/ s|uuid|ignore_&|' ${WRKSRC}/setup.py
+# disable detection of multiarch as it breaks with clang >= 13, which adds a
+# major.minor version number in -print-multiarch output, confusing Python
+	@${REINPLACE_CMD} -e 's|^MULTIARCH=.*|MULTIARCH=|' ${WRKSRC}/configure \
+		${WRKSRC}/configure.ac
 # Apply DISABLED_EXTENSIONS
 	@${ECHO_CMD} '*disabled*' > ${WRKSRC}/Modules/Setup.local
 .  for _module in ${DISABLED_EXTENSIONS}
 		@${ECHO_CMD} ${_module} >> ${WRKSRC}/Modules/Setup.local
 .  endfor
 
 post-install:
 .if ! ${PORT_OPTIONS:MDEBUG}
 	${RM} ${STAGEDIR}${PREFIX}/lib/libpython3.so						# Upstream Issue: https://bugs.python.org/issue17975
 .endif
 # This code block exists for the qemu-user enabled cross build environment.
 # When using this environment in poudriere, CC is not set to the default
 # of /usr/bin/cc and a cross-compile toolchain is used.  We need to hand
 # edit this so that the run time configuration for python matches what the
 # FreeBSD base system provides.  sbruno 02Aug2017
 .if ${CC} == /nxb-bin/usr/bin/cc
 	@${REINPLACE_CMD} -e 's=/nxb-bin==' \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/_sysconfigdata_${ABIFLAGS}_freebsd${OSREL:R}_.py
 	@cd ${WRKSRC} && ${SETENV} LD_LIBRARY_PATH=${WRKSRC} \
 		./python -E -m compileall -d ${PREFIX}/lib/python${PYTHON_VER} \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/_sysconfigdata_${ABIFLAGS}_freebsd${OSREL:R}_.py
 	@cd ${WRKSRC} && ${SETENV} LD_LIBRARY_PATH=${WRKSRC} \
 		./python -E -O -m compileall -d ${PREFIX}/lib/python${PYTHON_VER} \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/_sysconfigdata_${ABIFLAGS}_freebsd${OSREL:R}_.py
 	@${REINPLACE_CMD} -e 's=/nxb-bin==' \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/config-${PYTHON_VER}${ABIFLAGS}/Makefile
 .endif
 	for i in ${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/lib-dynload/*.so; do \
 		${STRIP_CMD} $$i; done								# Strip shared extensions
 	${INSTALL_DATA} ${WRKSRC}/Tools/gdb/libpython.py \
 		${STAGEDIR}${PREFIX}/lib/libpython${PYTHON_VER}${ABIFLAGS}.so.1.0-gdb.py
 
 .include <bsd.port.mk>
diff --git a/lang/python38/Makefile b/lang/python38/Makefile
index 68359a8579a8..f3dcec0757fa 100644
--- a/lang/python38/Makefile
+++ b/lang/python38/Makefile
@@ -1,150 +1,154 @@
 # Created by: Kubilay Kocak <koobs@FreeBSD.org>
 
 PORTNAME=	python
 DISTVERSION=	${PYTHON_DISTVERSION}
 CATEGORIES=	lang python
 MASTER_SITES=	PYTHON/ftp/python/${DISTVERSION}
 PKGNAMESUFFIX=	${PYTHON_SUFFIX}
 DISTNAME=	Python-${DISTVERSION}
 DIST_SUBDIR=	python
 
 MAINTAINER=	python@FreeBSD.org
 COMMENT=	Interpreted object-oriented programming language
 
 LICENSE=	PSFL
 
 LIB_DEPENDS=	libffi.so:devel/libffi
 
 USES=		cpe ncurses pathfix pkgconfig readline shebangfix ssl tar:xz
 PATHFIX_MAKEFILEIN=	Makefile.pre.in
 USE_LDCONFIG=	yes
 GNU_CONFIGURE=	yes
 python_CMD=	${PREFIX}/bin/python${PYTHON_DISTVERSION:R}
 SHEBANG_FILES=	Lib/*.py Lib/*/*.py Lib/*/*/*.py Lib/*/*/*/*.py
 SHEBANG_FILES+=	Lib/test/ziptestdata/exe_with_z64 \
 		Lib/test/ziptestdata/exe_with_zip \
 		Lib/test/ziptestdata/header.sh
 
 # Duplicate python.mk variables. TODO: Let lang/python?? ports use python.mk bits.
 PYTHON_VER=		${PYTHON_DISTVERSION:R}
 PYTHON_VERSION=		python${PYTHON_VER}
 PYTHON_SUFFIX=		${PYTHON_VER:S/.//g}
 
 DISABLED_EXTENSIONS=	_sqlite3 _tkinter _gdbm
 CONFIGURE_ARGS+=	--enable-shared --without-ensurepip \
 			--with-system-ffi
 CONFIGURE_ENV+=		OPT="" # Null out OPT to respect user CFLAGS and remove optimizations
 
 INSTALL_TARGET=		altinstall						# Don't want cloberring of unprefixed files
 
 TEST_TARGET=		buildbottest
 TEST_ARGS=		TESTOPTS=-j${MAKE_JOBS_NUMBER}
 
 MAKE_ARGS+=		INSTALL_SHARED="${INSTALL_LIB}"				# Strip shared library
 
 SUB_FILES=		pkg-message
 SUB_LIST=		PYTHON_SUFFIX=${PYTHON_SUFFIX}
 
 PLIST_SUB=		ABI=${ABIFLAGS} \
 			XY=${PYTHON_SUFFIX} \
 			XYDOT=${PYTHON_VER} \
 			XYZDOT=${DISTVERSION} \
 			OSMAJOR=${OSVERSION:C/([0-9]*)[0-9]{5}/\1/}		# For plat-freebsd* in pkg-plist. https://bugs.python.org/issue19554
 
 OPTIONS_DEFINE=		DEBUG IPV6 LIBMPDEC NLS PYMALLOC
 OPTIONS_DEFAULT=	LIBMPDEC PYMALLOC
 OPTIONS_RADIO=		HASH
 OPTIONS_RADIO_HASH=	FNV SIPHASH
 OPTIONS_SUB=		yes
 
 LIBMPDEC_DESC=		Use libmpdec from ports instead of bundled version
 NLS_DESC=		Enable gettext support for the locale module
 PYMALLOC_DESC=		Enable specialized mallocs
 
 HASH_DESC=		Hash Algorithm (PEP-456)
 FNV_DESC=		Modified Fowler-Noll-Vo Algorithm
 SIPHASH_DESC=		SipHash24 Algorithm
 
 FNV_CONFIGURE_ON=	--with-hash-algorithm=fnv
 SIPHASH_CONFIGURE_ON=	--with-hash-algorithm=siphash24
 
 DEBUG_CONFIGURE_WITH=	pydebug
 IPV6_CONFIGURE_ENABLE=	ipv6
 
 LIBMPDEC_CONFIGURE_ON=	--with-system-libmpdec
 LIBMPDEC_LIB_DEPENDS=	libmpdec.so:math/mpdecimal
 
 # Use CPPFLAGS over CFLAGS due to -I ordering, causing elementtree and pyexpat
 # to break in Python 2.7, or preprocessor complaints in Python >= 3.3
 # Upstream Issue: https://bugs.python.org/issue6299
 NLS_USES=		gettext
 NLS_CPPFLAGS=		-I${LOCALBASE}/include
 NLS_LIBS=		-L${LOCALBASE}/lib -lintl
 NLS_CONFIGURE_ENV_OFF=	ac_cv_lib_intl_textdomain=no ac_cv_header_libintl_h=no
 
 PYMALLOC_CONFIGURE_WITH=	pymalloc
 
 .include "${.CURDIR}/Makefile.version"
 .include <bsd.port.options.mk>
 
 .if ${PORT_OPTIONS:MDEBUG}
 ABIFLAGS:=	d${ABIFLAGS}
 .endif
 
 .if !empty(ABIFLAGS)
 PLIST_FILES+=	bin/python${PYTHON_VER}${ABIFLAGS} \
 		bin/python${PYTHON_VER}${ABIFLAGS}-config \
 		libdata/pkgconfig/python-${PYTHON_VER}${ABIFLAGS}.pc \
 		libdata/pkgconfig/python-${PYTHON_VER}${ABIFLAGS}-embed.pc
 .endif
 
 .if ${ARCH} == sparc64
 CFLAGS+=	-DPYTHON_DEFAULT_RECURSION_LIMIT=900
 .endif
 
 # See https://bugs.freebsd.org/115940 and https://bugs.freebsd.org/193650
 .if !exists(/usr/bin/ypcat) || defined(WITHOUT_NIS)
 PLIST_SUB+=	NO_NIS="@comment "
 DISABLED_EXTENSIONS+=	nis
 .else
 PLIST_SUB+=	NO_NIS=""
 .endif
 
 post-patch:
 # disable the detection of includes and library from e2fsprogs-libuuid,
 # which introduces hidden dependency and breaks build
 	@${REINPLACE_CMD} -e 's|uuid/uuid.h|ignore_&|' ${WRKSRC}/configure
 	@${REINPLACE_CMD} -e '/find_library_file/ s|uuid|ignore_&|' ${WRKSRC}/setup.py
+# disable detection of multiarch as it breaks with clang >= 13, which adds a
+# major.minor version number in -print-multiarch output, confusing Python
+	@${REINPLACE_CMD} -e 's|^MULTIARCH=.*|MULTIARCH=|' ${WRKSRC}/configure \
+		${WRKSRC}/configure.ac
 # Apply DISABLED_EXTENSIONS
 	@${ECHO_CMD} '*disabled*' > ${WRKSRC}/Modules/Setup.local
 .  for _module in ${DISABLED_EXTENSIONS}
 		@${ECHO_CMD} ${_module} >> ${WRKSRC}/Modules/Setup.local
 .  endfor
 
 post-install:
 .if ! ${PORT_OPTIONS:MDEBUG}
 	${RM} ${STAGEDIR}${PREFIX}/lib/libpython3.so						# Upstream Issue: https://bugs.python.org/issue17975
 .endif
 # This code block exists for the qemu-user enabled cross build environment.
 # When using this environment in poudriere, CC is not set to the default
 # of /usr/bin/cc and a cross-compile toolchain is used.  We need to hand
 # edit this so that the run time configuration for python matches what the
 # FreeBSD base system provides.  sbruno 02Aug2017
 .if ${CC} == /nxb-bin/usr/bin/cc
 	@${REINPLACE_CMD} -e 's=/nxb-bin==' \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/_sysconfigdata_${ABIFLAGS}_freebsd${OSREL:R}_.py
 	@cd ${WRKSRC} && ${SETENV} LD_LIBRARY_PATH=${WRKSRC} \
 		./python -E -m compileall -d ${PREFIX}/lib/python${PYTHON_VER} \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/_sysconfigdata_${ABIFLAGS}_freebsd${OSREL:R}_.py
 	@cd ${WRKSRC} && ${SETENV} LD_LIBRARY_PATH=${WRKSRC} \
 		./python -E -O -m compileall -d ${PREFIX}/lib/python${PYTHON_VER} \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/_sysconfigdata_${ABIFLAGS}_freebsd${OSREL:R}_.py
 	@${REINPLACE_CMD} -e 's=/nxb-bin==' \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/config-${PYTHON_VER}${ABIFLAGS}/Makefile
 .endif
 	for i in ${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/lib-dynload/*.so; do \
 		${STRIP_CMD} $$i; done								# Strip shared extensions
 	${INSTALL_DATA} ${WRKSRC}/Tools/gdb/libpython.py \
 		${STAGEDIR}${PREFIX}/lib/libpython${PYTHON_VER}${ABIFLAGS}.so.1.0-gdb.py
 
 .include <bsd.port.mk>
diff --git a/lang/python39/Makefile b/lang/python39/Makefile
index 4a0d31ba17f2..2d052cf3741d 100644
--- a/lang/python39/Makefile
+++ b/lang/python39/Makefile
@@ -1,151 +1,155 @@
 # Created by: Kubilay Kocak <koobs@FreeBSD.org>
 
 PORTNAME=	python
 DISTVERSION=	${PYTHON_DISTVERSION}
 CATEGORIES=	lang python
 MASTER_SITES=	PYTHON/ftp/python/${DISTVERSION}
 PKGNAMESUFFIX=	${PYTHON_SUFFIX}
 DISTNAME=	Python-${DISTVERSION}
 DIST_SUBDIR=	python
 
 MAINTAINER=	python@FreeBSD.org
 COMMENT=	Interpreted object-oriented programming language
 
 LICENSE=	PSFL
 
 LIB_DEPENDS=	libffi.so:devel/libffi
 
 USES=		compiler:c11 cpe ncurses pathfix pkgconfig readline \
 		shebangfix ssl tar:xz
 PATHFIX_MAKEFILEIN=	Makefile.pre.in
 USE_LDCONFIG=	yes
 GNU_CONFIGURE=	yes
 python_CMD=	${PREFIX}/bin/python${PYTHON_DISTVERSION:R}
 SHEBANG_FILES=	Lib/*.py Lib/*/*.py Lib/*/*/*.py Lib/*/*/*/*.py
 SHEBANG_FILES+=	Lib/test/ziptestdata/exe_with_z64 \
 		Lib/test/ziptestdata/exe_with_zip \
 		Lib/test/ziptestdata/header.sh
 
 # Duplicate python.mk variables. TODO: Let lang/python?? ports use python.mk bits.
 PYTHON_VER=		${PYTHON_DISTVERSION:R}
 PYTHON_VERSION=		python${PYTHON_VER}
 PYTHON_SUFFIX=		${PYTHON_VER:S/.//g}
 
 DISABLED_EXTENSIONS=	_sqlite3 _tkinter _gdbm
 CONFIGURE_ARGS+=	--enable-shared --without-ensurepip \
 			--with-system-ffi
 CONFIGURE_ENV+=		OPT="" # Null out OPT to respect user CFLAGS and remove optimizations
 
 INSTALL_TARGET=		altinstall						# Don't want cloberring of unprefixed files
 
 TEST_TARGET=		buildbottest
 TEST_ARGS=		TESTOPTS=-j${MAKE_JOBS_NUMBER}
 
 MAKE_ARGS+=		INSTALL_SHARED="${INSTALL_LIB}"				# Strip shared library
 
 SUB_FILES=		pkg-message
 SUB_LIST=		PYTHON_SUFFIX=${PYTHON_SUFFIX}
 
 PLIST_SUB=		ABI=${ABIFLAGS} \
 			XY=${PYTHON_SUFFIX} \
 			XYDOT=${PYTHON_VER} \
 			XYZDOT=${DISTVERSION} \
 			OSMAJOR=${OSVERSION:C/([0-9]*)[0-9]{5}/\1/}		# For plat-freebsd* in pkg-plist. https://bugs.python.org/issue19554
 
 OPTIONS_DEFINE=		DEBUG IPV6 LIBMPDEC NLS PYMALLOC
 OPTIONS_DEFAULT=	LIBMPDEC PYMALLOC
 OPTIONS_RADIO=		HASH
 OPTIONS_RADIO_HASH=	FNV SIPHASH
 OPTIONS_SUB=		yes
 
 LIBMPDEC_DESC=		Use libmpdec from ports instead of bundled version
 NLS_DESC=		Enable gettext support for the locale module
 PYMALLOC_DESC=		Enable specialized mallocs
 
 HASH_DESC=		Hash Algorithm (PEP-456)
 FNV_DESC=		Modified Fowler-Noll-Vo Algorithm
 SIPHASH_DESC=		SipHash24 Algorithm
 
 FNV_CONFIGURE_ON=	--with-hash-algorithm=fnv
 SIPHASH_CONFIGURE_ON=	--with-hash-algorithm=siphash24
 
 DEBUG_CONFIGURE_WITH=	pydebug
 IPV6_CONFIGURE_ENABLE=	ipv6
 
 LIBMPDEC_CONFIGURE_ON=	--with-system-libmpdec
 LIBMPDEC_LIB_DEPENDS=	libmpdec.so:math/mpdecimal
 
 # Use CPPFLAGS over CFLAGS due to -I ordering, causing elementtree and pyexpat
 # to break in Python 2.7, or preprocessor complaints in Python >= 3.3
 # Upstream Issue: https://bugs.python.org/issue6299
 NLS_USES=		gettext
 NLS_CPPFLAGS=		-I${LOCALBASE}/include
 NLS_LIBS=		-L${LOCALBASE}/lib -lintl
 NLS_CONFIGURE_ENV_OFF=	ac_cv_lib_intl_textdomain=no ac_cv_header_libintl_h=no
 
 PYMALLOC_CONFIGURE_WITH=	pymalloc
 
 .include "${.CURDIR}/Makefile.version"
 .include <bsd.port.options.mk>
 
 .if ${PORT_OPTIONS:MDEBUG}
 ABIFLAGS:=	d${ABIFLAGS}
 .endif
 
 .if !empty(ABIFLAGS)
 PLIST_FILES+=	bin/python${PYTHON_VER}${ABIFLAGS} \
 		bin/python${PYTHON_VER}${ABIFLAGS}-config \
 		libdata/pkgconfig/python-${PYTHON_VER}${ABIFLAGS}.pc \
 		libdata/pkgconfig/python-${PYTHON_VER}${ABIFLAGS}-embed.pc
 .endif
 
 .if ${ARCH} == sparc64
 CFLAGS+=	-DPYTHON_DEFAULT_RECURSION_LIMIT=900
 .endif
 
 # See https://bugs.freebsd.org/115940 and https://bugs.freebsd.org/193650
 .if !exists(/usr/bin/ypcat) || defined(WITHOUT_NIS)
 PLIST_SUB+=	NO_NIS="@comment "
 DISABLED_EXTENSIONS+=	nis
 .else
 PLIST_SUB+=	NO_NIS=""
 .endif
 
 post-patch:
 # disable the detection of includes and library from e2fsprogs-libuuid,
 # which introduces hidden dependency and breaks build
 	@${REINPLACE_CMD} -e 's|uuid/uuid.h|ignore_&|' ${WRKSRC}/configure
 	@${REINPLACE_CMD} -e '/find_library_file/ s|uuid|ignore_&|' ${WRKSRC}/setup.py
+# disable detection of multiarch as it breaks with clang >= 13, which adds a
+# major.minor version number in -print-multiarch output, confusing Python
+	@${REINPLACE_CMD} -e 's|^MULTIARCH=.*|MULTIARCH=|' ${WRKSRC}/configure \
+		${WRKSRC}/configure.ac
 # Apply DISABLED_EXTENSIONS
 	@${ECHO_CMD} '*disabled*' > ${WRKSRC}/Modules/Setup.local
 .  for _module in ${DISABLED_EXTENSIONS}
 		@${ECHO_CMD} ${_module} >> ${WRKSRC}/Modules/Setup.local
 .  endfor
 
 post-install:
 .if ! ${PORT_OPTIONS:MDEBUG}
 	${RM} ${STAGEDIR}${PREFIX}/lib/libpython3.so						# Upstream Issue: https://bugs.python.org/issue17975
 .endif
 # This code block exists for the qemu-user enabled cross build environment.
 # When using this environment in poudriere, CC is not set to the default
 # of /usr/bin/cc and a cross-compile toolchain is used.  We need to hand
 # edit this so that the run time configuration for python matches what the
 # FreeBSD base system provides.  sbruno 02Aug2017
 .if ${CC} == /nxb-bin/usr/bin/cc
 	@${REINPLACE_CMD} -e 's=/nxb-bin==' \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/_sysconfigdata_${ABIFLAGS}_freebsd${OSREL:R}_.py
 	@cd ${WRKSRC} && ${SETENV} LD_LIBRARY_PATH=${WRKSRC} \
 		./python -E -m compileall -d ${PREFIX}/lib/python${PYTHON_VER} \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/_sysconfigdata_${ABIFLAGS}_freebsd${OSREL:R}_.py
 	@cd ${WRKSRC} && ${SETENV} LD_LIBRARY_PATH=${WRKSRC} \
 		./python -E -O -m compileall -d ${PREFIX}/lib/python${PYTHON_VER} \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/_sysconfigdata_${ABIFLAGS}_freebsd${OSREL:R}_.py
 	@${REINPLACE_CMD} -e 's=/nxb-bin==' \
 		${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/config-${PYTHON_VER}${ABIFLAGS}/Makefile
 .endif
 	for i in ${STAGEDIR}${PREFIX}/lib/python${PYTHON_VER}/lib-dynload/*.so; do \
 		${STRIP_CMD} $$i; done								# Strip shared extensions
 	${INSTALL_DATA} ${WRKSRC}/Tools/gdb/libpython.py \
 		${STAGEDIR}${PREFIX}/lib/libpython${PYTHON_VER}${ABIFLAGS}.so.1.0-gdb.py
 
 .include <bsd.port.mk>