diff --git a/biology/hyphy/Makefile b/biology/hyphy/Makefile
index 732141e3149c..0373fc76233c 100644
--- a/biology/hyphy/Makefile
+++ b/biology/hyphy/Makefile
@@ -1,29 +1,29 @@
 PORTNAME=	hyphy
-DISTVERSION=	2.5.48
+DISTVERSION=	2.5.49
 CATEGORIES=	biology
 
 MAINTAINER=	jrm@FreeBSD.org
 COMMENT=	Hypothesis testing using Phylogenies
 WWW=		https://www.hyphy.org/
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 ONLY_FOR_ARCHS=	aarch64 amd64 armv7 i386 powerpc powerpc64 powerpc64le
 
 LIB_DEPENDS=	libcurl.so:ftp/curl
 TEST_DEPENDS=	bash:shells/bash
 
 USES=		cmake:insource,testing localbase:ldflags # tests fail in outsource build, see https://github.com/veg/hyphy/issues/1528
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	veg
 
 OPTIONS_DEFINE=	AVX
 AVX_DESC=	Advanced vector extensions support
 
 AVX_CMAKE_OFF=	-DNOAVX:BOOL=ON
 
-# All tests pass as of DISTVERSION=2.5.46hf1
+# FEL test is failing. See https://github.com/veg/hyphy/issues/1585
 
 .include <bsd.port.mk>
diff --git a/biology/hyphy/distinfo b/biology/hyphy/distinfo
index 0216573f12cb..4608f46ed15d 100644
--- a/biology/hyphy/distinfo
+++ b/biology/hyphy/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1678030854
-SHA256 (veg-hyphy-2.5.48_GH0.tar.gz) = 61932021e989f955c2879cf0966c5abe6581774a4dafda54df72a1b7c3407b95
-SIZE (veg-hyphy-2.5.48_GH0.tar.gz) = 5648653
+TIMESTAMP = 1679670987
+SHA256 (veg-hyphy-2.5.49_GH0.tar.gz) = 00a30f8b0e8bdc0a6f0a55201082d72cba9f7bd29e1e0e0088a3cedb3dbfeed4
+SIZE (veg-hyphy-2.5.49_GH0.tar.gz) = 5648834