diff --git a/science/py-hoomd-blue/Makefile b/science/py-hoomd-blue/Makefile
index e7929a59883d..13a2b9fe990f 100644
--- a/science/py-hoomd-blue/Makefile
+++ b/science/py-hoomd-blue/Makefile
@@ -1,71 +1,69 @@
 PORTNAME=	hoomd-blue
 DISTVERSIONPREFIX=	v
 DISTVERSION=	4.9.1
 CATEGORIES=	science # physics
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Molecular dynamics and Monte Carlo soft matter simulation
 WWW=		https://glotzerlab.engin.umich.edu/hoomd-blue/ \
 		https://github.com/glotzerlab/hoomd-blue
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BROKEN_FreeBSD_15=	compilation fails with clang-19, see https://github.com/glotzerlab/hoomd-blue/issues/1924
-
 BUILD_DEPENDS=	pybind11>0:devel/pybind11
 
 USES=		cmake:testing compiler:c++17-lang eigen:3 localbase:ldflags python shebangfix # see https://github.com/glotzerlab/hoomd-blue/issues/1204
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	glotzerlab
 
 GH_TUPLE=	glotzerlab:upp11:0c1fb8d:glotzerlab_upp11/hoomd/extern/upp11 \
 		glotzerlab:nano-signal-slot:34223a4:glotzerlab_nano_signal_slot/hoomd/extern/nano-signal-slot \
 		glotzerlab:quickhull:1ffbc6f:glotzerlab_quickhull/hoomd/extern/quickhull \
 		glotzerlab:random123:a2c4f04:glotzerlab_random123/hoomd/extern/random123 \
 		glotzerlab:HIP:d211f99:glotzerlab_HIP/hoomd/extern/HIP \
 		glotzerlab:hipCUB:c70e193:glotzerlab_hipCUB/hoomd/extern/hipCUB \
 		mphowardlab:neighbor:ba0f068:mphowardlab_neighbor/hoomd/extern/neighbor \
 		mphowardlab:hipper:b6da049:mphowardlab_hipper/hoomd/extern/hipper
 
 SHEBANG_GLOB=	*.sh
 
 CMAKE_OFF=	BUILD_TESTING
 
 LDFLAGS+=	-lexecinfo
 
 OPTIONS_DEFINE=		TBB
 OPTIONS_SINGLE=		MPI
 OPTIONS_SINGLE_MPI=	NOMPI MPICH OPENMPI
 OPTIONS_DEFAULT=	MPICH TBB
 OPTIONS_SUB=		yes
 
 NOMPI_DESC=		Build without parallel processing support
 NOMPI_CMAKE_ON=		-DENABLE_MPI=OFF
 
 MPICH_USES=		mpi:mpich
 MPICH_CMAKE_ON=		-DENABLE_MPI=ON
 MPICH_BUILD_DEPENDS=	cereal>0:devel/cereal
 
 OPENMPI_USES=		mpi:openmpi
 OPENMPI_CMAKE_ON=	-DENABLE_MPI=ON
 OPENMPI_BUILD_DEPENDS=	cereal>0:devel/cereal
 OPENMPI_BROKEN=		see https://github.com/glotzerlab/hoomd-blue/issues/1397
 
 TBB_DESC=		Enable support for Threading Building Blocks (TBB)
 TBB_CMAKE_BOOL=		ENABLE_TBB
 TBB_LIB_DEPENDS=	libtbb.so:devel/onetbb
 
 # the test mpi-test_communication requires excessive resources, see https://github.com/glotzerlab/hoomd-blue/issues/1396
 
 .include <bsd.port.pre.mk>
 
 post-patch:
 .if ${COMPILER_TYPE} == clang
 	@${REINPLACE_CMD} -e 's|std::unary_function|std::__unary_function|' \
 		${WRKSRC}/hoomd/ParticleData.cc
 .endif
 
 .include <bsd.port.post.mk>
diff --git a/science/py-hoomd-blue/files/patch-hoomd_GPUFlags.h b/science/py-hoomd-blue/files/patch-hoomd_GPUFlags.h
new file mode 100644
index 000000000000..9b655f55b4af
--- /dev/null
+++ b/science/py-hoomd-blue/files/patch-hoomd_GPUFlags.h
@@ -0,0 +1,18 @@
+Fix build with LLVM 19
+
+/wrkdirs/usr/ports/science/py-hoomd-blue/work/hoomd-blue-4.9.0/hoomd/GPUFlags.h:160:27:
+error: reference to non-static member function must be called
+  160 |     this->resetFlags(from.readFlags);
+      |                      ~~~~~^~~~~~~~~
+
+--- hoomd/GPUFlags.h.orig	2024-10-31 16:09:15 UTC
++++ hoomd/GPUFlags.h
+@@ -157,7 +157,7 @@ GPUFlags<T>::GPUFlags(const GPUFlags& from)
+     memclear();
+ 
+     // copy over the data to the new GPUFlags
+-    this->resetFlags(from.readFlags);
++    this->resetFlags(from.readFlags());
+     }
+ 
+ template<class T> GPUFlags<T>& GPUFlags<T>::operator=(const GPUFlags& rhs)
diff --git a/science/py-hoomd-blue/files/patch-hoomd_extern_nano-signal-slot_nano__signal__slot.hpp b/science/py-hoomd-blue/files/patch-hoomd_extern_nano-signal-slot_nano__signal__slot.hpp
new file mode 100644
index 000000000000..cd3fce241f6d
--- /dev/null
+++ b/science/py-hoomd-blue/files/patch-hoomd_extern_nano-signal-slot_nano__signal__slot.hpp
@@ -0,0 +1,30 @@
+Fix build with LLVM 19
+
+/wrkdirs/usr/ports/science/py-hoomd-blue/work/hoomd-blue-4.9.0/hoomd/extern/nano-signal-slot/nano_signal_slot.hpp:46:45:
+error: a template argument list is expected after a name prefixed by the template keyword [-Wmissing-template-arg-list-after-template-kw]
+   46 |         Observer::insert(Delegate::template bind (instance), this);
+      |                                             ^
+/wrkdirs/usr/ports/science/py-hoomd-blue/work/hoomd-blue-4.9.0/hoomd/extern/nano-signal-slot/nano_signal_slot.hpp:87:45:
+error: a template argument list is expected after a name prefixed by the template keyword [-Wmissing-template-arg-list-after-template-kw]
+   87 |         Observer::remove(Delegate::template bind (instance), this);
+
+--- hoomd/extern/nano-signal-slot/nano_signal_slot.hpp.orig	2016-07-13 20:06:52 UTC
++++ hoomd/extern/nano-signal-slot/nano_signal_slot.hpp
+@@ -43,7 +43,7 @@ class Signal<RT(Args...)> : private Observer
+     template <typename L>
+     void connect(L* instance)
+     {
+-        Observer::insert(Delegate::template bind (instance), this);
++        Observer::insert(Delegate::bind (instance), this);
+     }
+     template <typename L>
+     void connect(L& instance)
+@@ -84,7 +84,7 @@ class Signal<RT(Args...)> : private Observer
+     template <typename L>
+     void disconnect(L* instance)
+     {
+-        Observer::remove(Delegate::template bind (instance), this);
++        Observer::remove(Delegate::bind (instance), this);
+     }
+     template <typename L>
+     void disconnect(L& instance)