diff --git a/biology/ugene/Makefile b/biology/ugene/Makefile
index 4fd816e3b800..f1d8b2834ae3 100644
--- a/biology/ugene/Makefile
+++ b/biology/ugene/Makefile
@@ -1,66 +1,64 @@
 # Created by: Hannes Hauswedell <h2+fbsdports@fsfe.org>
 
 PORTNAME=	ugene
-PORTVERSION=	38.0
+PORTVERSION=	38.1
 CATEGORIES=	biology science
 
 MAINTAINER=	h2+fbsdports@fsfe.org
 COMMENT=	Integrated bioinformatics toolkit
 
 LICENSE=	GPLv2+
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 BROKEN_aarch64=	Fails to build: invokes x86 asm
 BROKEN_riscv64=	Fails to build: invokes x86 asm
-BROKEN=		Does not fetch: size mismatch (expected 23448730, actual 23446282)
 
 RUN_DEPENDS=	bash:shells/bash
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	ugeneunipro
 
 USES=		desktop-file-utils gl qmake qt:5 shared-mime-info sqlite xorg
 USE_GL=		gl glu
 USE_QT=		buildtools_build linguisttools_build \
 		core gui network opengl printsupport scripttools script \
 		sql svg testlib widgets xml \
 		imageformats_run
 USE_XORG=	x11 xtst
 
 QMAKE_ARGS=	INSTALL_PREFIX="${PREFIX}" UGENE_INSTALL_DATA="${DATADIR}" \
 		INSTALL_MANDIR="${MAN1PREFIX}/man" \
 		UGENE_LRELEASE="${LRELEASE}" UGENE_LUPDATE="${LUPDATE}" \
 		UGENE_USE_BUNDLED_SQLITE=0
 ALL_TARGET=	release
 CXXFLAGS_i386=	-msse2
 
 OPTIONS_DEFINE=	OPENCL
 
 OPENCL_QMAKE_ON=	UGENE_OPENCL_DETECTED=1
 
 .include <bsd.port.pre.mk>
 
-.if ${ARCH} == amd64
-# XXX: need to manually tell the build we are on x64
-QMAKE_ARGS+=	CONFIG+=x64
+.if ${ARCH} == i386
+QMAKE_ARGS+=	CONFIG+=x86
 .endif
 
 post-patch:
 # yes, bash is required, stuff will not execute with sh
 	@${REINPLACE_CMD} -e 's|/bin/bash|/usr/bin/env bash|' \
 		${WRKSRC}/src/gen_bin_script.cmd \
 		${WRKSRC}/installer/_common_data/ugene
 	@${REINPLACE_CMD} -e 's|-bit version|& for ${OPSYS}/${ARCH}|' \
 		${WRKSRC}/src/ugeneui/src/main_window/AboutDialogController.cpp
 	@${REINPLACE_CMD} 's, -lbreakpad$$$$D,,' \
 		${WRKSRC}/src/corelibs/U2Private/U2Private.pri \
 		${WRKSRC}/src/plugins_checker/plugins_checker.pri \
 		${WRKSRC}/src/ugenecl/ugenecl.pri \
 		${WRKSRC}/src/ugeneui/ugeneui.pri
 	@${REINPLACE_CMD} -e '218,220s|NULL)|false)|' \
 		${WRKSRC}/src/plugins/GUITestBase/src/GTUtilsMdi.cpp
 
 post-stage:
 	@cd ${STAGEDIR}${PREFIX} && ${RM} bin/ecp.* lib/ugene/ecp.*
 
 .include <bsd.port.post.mk>
diff --git a/biology/ugene/distinfo b/biology/ugene/distinfo
index 5265749cd4bf..dfd53e61071d 100644
--- a/biology/ugene/distinfo
+++ b/biology/ugene/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1616417068
-SHA256 (ugeneunipro-ugene-38.0_GH0.tar.gz) = e0eb0ccf02e43bef4dfba707fb25b94e2d77476fcfef853ab7d7222f44fffa92
-SIZE (ugeneunipro-ugene-38.0_GH0.tar.gz) = 23448730
+TIMESTAMP = 1616742529
+SHA256 (ugeneunipro-ugene-38.1_GH0.tar.gz) = f5e208df0481c2dfe804817d6bc7e8a1d6236e8cbff3d8b874745873492a56d6
+SIZE (ugeneunipro-ugene-38.1_GH0.tar.gz) = 23446767