diff --git a/math/blis/Makefile b/math/blis/Makefile
index 2793d3538f46..baa73955f9e3 100644
--- a/math/blis/Makefile
+++ b/math/blis/Makefile
@@ -1,71 +1,75 @@
 PORTNAME=	blis
 PORTVERSION=	0.9.0
 PORTREVISION=	2
 CATEGORIES=	math
 
 MAINTAINER=	jmd@FreeBSD.org
 COMMENT=	Software framework for high-performance BLAS-like libraries
 WWW=		https://github.com/flame/blis
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	bash:shells/bash
 
 USES=		compiler gmake perl5 python shebangfix
 USE_GITHUB=	yes
 GH_ACCOUNT=	flame
 USE_LDCONFIG=	yes
 USE_PERL5=	build
 SHEBANG_FILES=	build/flatten-headers.py
 
 OPTIONS_DEFINE=	PARA CBLAS
 PARA_DESC=	use pthread parallelization
 CBLAS_DESC=	build the CBLAS compatibility layer
 OPTIONS_DEFAULT=	PARA CBLAS
 OPTIONS_SUB=		yes
 
 CFLAGS_riscv64=	-mno-relax
 HAS_CONFIGURE=	yes
 
 TEST_TARGET=	test
 
 .include <bsd.port.options.mk>
 
 # enable BLAS and static/shared libs by default
 CONFIGURE_ARGS+=	--enable-blas \
 			--prefix=${PREFIX} \
 			--enable-shared \
 			--enable-static
 #--prefix=PREFIX
 
 .if ${PORT_OPTIONS:MPARA}
 CONFIGURE_ARGS+=	-t pthreads
 .endif
 
 .if ${PORT_OPTIONS:MCBLAS}
 CONFIGURE_ARGS+=	--enable-cblas
 .endif
 
 .if ${ARCH} == amd64
 CONFIGURE_ARGS+=	x86_64
 PLIST_SUB+=	ARCH="x86_64"
 .elif ${ARCH:Mpowerpc64*}
 CONFIGURE_ARGS+=	power9
 PLIST_SUB+=	ARCH="power9"
 USE_GCC=	yes
 .else
 CONFIGURE_ARGS+=	generic
 PLIST_SUB+=	ARCH="generic"
 .endif
 
 .include <bsd.port.pre.mk>
 
+.if ${COMPILER_TYPE} == clang && ${COMPILER_VERSION} >= 190
+EXTRA_PATCHES+=	${PATCHDIR}/extra-patch-config_knl_make__defs.mk
+.endif
+
 .if ${CHOSEN_COMPILER_TYPE} == gcc
 USE_GCC=	yes
 .endif
 
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PREFIX}/lib/libblis.so.4.0.0
 
 .include <bsd.port.post.mk>
diff --git a/math/blis/files/extra-patch-config_knl_make__defs.mk b/math/blis/files/extra-patch-config_knl_make__defs.mk
new file mode 100644
index 000000000000..e2b980ba641d
--- /dev/null
+++ b/math/blis/files/extra-patch-config_knl_make__defs.mk
@@ -0,0 +1,20 @@
+--- config/knl/make_defs.mk.orig	2022-04-01 13:12:06 UTC
++++ config/knl/make_defs.mk
+@@ -81,7 +81,7 @@ ifeq ($(CC_VENDOR),clang)
+ CKVECFLAGS     := -xMIC-AVX512
+ else
+ ifeq ($(CC_VENDOR),clang)
+-CKVECFLAGS     := -mavx512f -mavx512pf -mfpmath=sse -march=knl
++CKVECFLAGS     := -mavx512f -mfpmath=sse -march=knl
+ else
+ $(error gcc, icc, or clang is required for this configuration.)
+ endif
+@@ -105,7 +105,7 @@ ifeq ($(CC_VENDOR),clang)
+ CRVECFLAGS     := -xMIC-AVX512
+ else
+ ifeq ($(CC_VENDOR),clang)
+-CRVECFLAGS     := -march=knl -mno-avx512f -mno-avx512pf -mno-avx512er -mno-avx512cd -funsafe-math-optimizations -ffp-contract=fast
++CRVECFLAGS     := -march=knl -mno-avx512f -mno-avx512cd -funsafe-math-optimizations -ffp-contract=fast
+ else
+ $(error gcc, icc, or clang is required for this configuration.)
+ endif