diff --git a/science/InsightToolkit/files/patch-Modules_ThirdParty_VNL_src_vxl_vcl_tests_test__preprocessor.cxx b/science/InsightToolkit/files/patch-Modules_ThirdParty_VNL_src_vxl_vcl_tests_test__preprocessor.cxx
new file mode 100644
index 000000000000..cd13183d7c5f
--- /dev/null
+++ b/science/InsightToolkit/files/patch-Modules_ThirdParty_VNL_src_vxl_vcl_tests_test__preprocessor.cxx
@@ -0,0 +1,14 @@
+Fix build with CMake >= 3.29.0. Support for the Comeau compiler was removed.
+
+--- Modules/ThirdParty/VNL/src/vxl/vcl/tests/test_preprocessor.cxx.orig	2022-11-24 13:15:41 UTC
++++ Modules/ThirdParty/VNL/src/vxl/vcl/tests/test_preprocessor.cxx
+@@ -9,8 +9,7 @@ int test_preprocessor_main(int /*argc*/,char* /*argv*/
+ int test_preprocessor_main(int /*argc*/,char* /*argv*/[])
+ {
+   constexpr unsigned compiler_count
+-      = VXL_COMPILER_IS_Comeau
+-        + VXL_COMPILER_IS_Intel
++      = VXL_COMPILER_IS_Intel
+         + VXL_COMPILER_IS_PathScale
+         + VXL_COMPILER_IS_Embarcadero
+         + VXL_COMPILER_IS_Borland