diff --git a/devel/py-cbor2/Makefile b/devel/py-cbor2/Makefile
index 6b47c5a50140..43aa728eee48 100644
--- a/devel/py-cbor2/Makefile
+++ b/devel/py-cbor2/Makefile
@@ -1,26 +1,26 @@
 # Created by: Dan Langille <dvl@FreeBSD.org>
 
 PORTNAME=	cbor2
-PORTVERSION=	5.4.2
+PORTVERSION=	5.4.3
 CATEGORIES=	devel python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	dvl@FreeBSD.org
 COMMENT=	Pure Python CBOR (de)serializer with extensive tag support
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools_scm>=1.7.0:devel/py-setuptools_scm@${PY_FLAVOR}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pytest>0:devel/py-pytest@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}cbor>0:devel/py-cbor@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}objgraph>0:devel/py-objgraph@${PY_FLAVOR}
 
 USES=		python:3.6+
 USE_PYTHON=	autoplist concurrent distutils
 
 do-test:
 	@cd ${WRKSRC} && ${PYTHON_CMD} -m pytest -v -rs
 
 .include <bsd.port.mk>
diff --git a/devel/py-cbor2/distinfo b/devel/py-cbor2/distinfo
index df31956e5100..5ea126378e18 100644
--- a/devel/py-cbor2/distinfo
+++ b/devel/py-cbor2/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1646916664
-SHA256 (cbor2-5.4.2.tar.gz) = e283e70b55a049ff364cc5e648fde587e4d9b0e87e4b2664c69e639135e6b3b8
-SIZE (cbor2-5.4.2.tar.gz) = 85847
+TIMESTAMP = 1655208282
+SHA256 (cbor2-5.4.3.tar.gz) = 62b863c5ee6ced4032afe948f3c1484f375550995d3b8498145237fe28e546c2
+SIZE (cbor2-5.4.3.tar.gz) = 86499
diff --git a/devel/py-cbor2/files/patch-setup.cfg b/devel/py-cbor2/files/patch-setup.cfg
deleted file mode 100644
index 96a073370459..000000000000
--- a/devel/py-cbor2/files/patch-setup.cfg
+++ /dev/null
@@ -1,37 +0,0 @@
-# Added encoding declaration to setup.cfg
-# https://github.com/agronholm/cbor2/commit/ba05c122
-# https://github.com/agronholm/cbor2/issues/38
-
-# pytest uses py which vendors iniconfig, which isn't unicode aware
-# Patch out unicode characters for now
-# https://github.com/pytest-dev/pytest/issues/3799
-# https://github.com/RonnyPfannschmidt/iniconfig/issues/5
-# https://github.com/RonnyPfannschmidt/iniconfig/issues/4
-
-# coverage is not a compulsory dependency
-# this block clobbers ports pytest args
-
---- setup.cfg.orig	2021-10-14 11:14:02 UTC
-+++ setup.cfg
-@@ -1,8 +1,9 @@
-+# coding: utf-8
- [metadata]
- name = cbor2
- description = Pure Python CBOR (de)serializer with extensive tag support
- long_description = file: README.rst
--author = Alex Grönholm
-+author = Alex Gronholm
- author_email = alex.gronholm@nextday.fi
- maintainer = Kio Smallwood (Sekenre)
- maintainer_email = kio@mothers-arms.co.uk
-@@ -34,10 +35,6 @@ doc = 
- doc = 
- 	sphinx_rtd_theme
- 	sphinx-autodoc-typehints >= 1.2.0
--
--[tool:pytest]
--addopts = -rsx --cov --tb=short
--testpaths = tests
- 
- [coverage:run]
- source = cbor2