diff --git a/biology/py-pysam/Makefile b/biology/py-pysam/Makefile
index d98fc9f8f29a..a000663bc8a6 100644
--- a/biology/py-pysam/Makefile
+++ b/biology/py-pysam/Makefile
@@ -1,16 +1,19 @@
 PORTNAME=	pysam
 DISTVERSION=	0.19.1
 CATEGORIES=	biology python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Python module for reading, manipulating and writing genomic data sets
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/COPYING
 
+BROKEN_arm64=	conflicting symbol (libchtslib libcsamtools ...) : $d.6
+BROKEN_riscv6=	conflicting symbol (libchtslib libcsamtools ...): .Lline_table_start0
+
 USES=		gmake python:3.6-3.9
 USE_PYTHON=	autoplist distutils cython cython_run
 
 .include <bsd.port.mk>