diff --git a/biology/py-biopython/Makefile b/biology/py-biopython/Makefile
index 7ca215dafc49..b9f9e1bdf684 100644
--- a/biology/py-biopython/Makefile
+++ b/biology/py-biopython/Makefile
@@ -1,32 +1,32 @@
 PORTNAME=	biopython
-DISTVERSION=	1.80
+DISTVERSION=	1.81
 CATEGORIES=	biology python
 MASTER_SITES=	http://www.biopython.org/DIST/
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	mauricio@arareko.net
 COMMENT=	Collection of Python modules for bioinformatics
 WWW=		https://biopython.org/
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.rst
 
 BUILD_DEPENDS=	${PYNUMPY}
 RUN_DEPENDS=	${PYNUMPY}
 
 USES=		python:3.7+
 USE_PYTHON=	distutils autoplist
 
 OPTIONS_DEFINE=		REPORTLAB
 OPTIONS_DEFAULT=	REPORTLAB
 
 REPORTLAB_DESC=		PDF support in Bio.Graphics module
 REPORTLAB_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}reportlab>0:print/py-reportlab@${PY_FLAVOR}
 
 post-install:
 	@${STRIP_CMD} \
 		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/Bio/*.so \
 		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/Bio/*/*.so \
 		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/Bio/*/*/*.so \
 
 .include <bsd.port.mk>
diff --git a/biology/py-biopython/distinfo b/biology/py-biopython/distinfo
index c4c5e3fdea71..eb6174add02f 100644
--- a/biology/py-biopython/distinfo
+++ b/biology/py-biopython/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1669897294
-SHA256 (biopython-1.80.tar.gz) = 52805e9af88767e450e2df8113b5bc59e964e2e8a7bb803a83570bdbb51c0e43
-SIZE (biopython-1.80.tar.gz) = 17924553
+TIMESTAMP = 1678108052
+SHA256 (biopython-1.81.tar.gz) = 2cf38112b6d8415ad39d6a611988cd11fb5f33eb09346666a87263beba9614e0
+SIZE (biopython-1.81.tar.gz) = 19324875