diff --git a/biology/trimadap/Makefile b/biology/trimadap/Makefile
index 800b2a18d6fe..7d5d5a58e05f 100644
--- a/biology/trimadap/Makefile
+++ b/biology/trimadap/Makefile
@@ -1,27 +1,26 @@
 PORTNAME=	trimadap
-DISTVERSION=	0.1-3
-DISTVERSIONSUFFIX=	-gddfef21
-PORTREVISION=	1
+DISTVERSION=	0.1-4
+DISTVERSIONSUFFIX=	-gec5a764
 CATEGORIES=	biology
 
 MAINTAINER=	jwb@FreeBSD.org
 COMMENT=	Trim adapter sequences from Illumina data using heuristic rules
 WWW=		https://github.com/lh3/trimadap
 
-LICENSE=	GPLv2
+LICENSE=	MIT
 
-ONLY_FOR_ARCHS=		amd64 i386 powerpc64le
-ONLY_FOR_ARCHS_REASON=	uses hard-coded SSE instructions
+BUILD_DEPENDS=	simde>0:devel/simde
 
+USES=		localbase
 USE_GITHUB=	yes
 GH_ACCOUNT=	lh3
 
 PLIST_FILES=	bin/trimadap-mt
 
 CFLAGS_i386=	-msse2
 CFLAGS_powerpc64le=	-DNO_WARN_X86_INTRINSICS
 
 do-install:
 	${INSTALL_PROGRAM} ${WRKSRC}/trimadap-mt ${STAGEDIR}${PREFIX}/bin
 
 .include <bsd.port.mk>
diff --git a/biology/trimadap/distinfo b/biology/trimadap/distinfo
index 99e06ce2a75b..59177ee4abda 100644
--- a/biology/trimadap/distinfo
+++ b/biology/trimadap/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1522773176
-SHA256 (lh3-trimadap-0.1-3-gddfef21_GH0.tar.gz) = c2c42a3257d37b12be3523ed0d4415bddd401d72b99b05ba4ae33afaa3c3f373
-SIZE (lh3-trimadap-0.1-3-gddfef21_GH0.tar.gz) = 13138
+TIMESTAMP = 1729109026
+SHA256 (lh3-trimadap-0.1-4-gec5a764_GH0.tar.gz) = fa842c705028054e13dc5be6aab5feb621b0ac54c2ca5bee3ab9eb9046a55ac4
+SIZE (lh3-trimadap-0.1-4-gec5a764_GH0.tar.gz) = 13268
diff --git a/biology/trimadap/files/patch-ksw.c b/biology/trimadap/files/patch-ksw.c
new file mode 100644
index 000000000000..e82692c1ee80
--- /dev/null
+++ b/biology/trimadap/files/patch-ksw.c
@@ -0,0 +1,13 @@
+--- ksw.c.orig	2024-10-16 19:52:35 UTC
++++ ksw.c
+@@ -26,7 +26,9 @@
+ #include <stdlib.h>
+ #include <stdint.h>
+ #include <string.h>
+-#include <emmintrin.h>
++// #include <emmintrin.h>
++#define SIMDE_ENABLE_NATIVE_ALIASES
++#include <simde/x86/sse2.h>
+ #include "ksw.h"
+ 
+ #ifdef __GNUC__