diff --git a/biology/vsearch/Makefile b/biology/vsearch/Makefile
index 341b921fbf76..85bc37e94c4e 100644
--- a/biology/vsearch/Makefile
+++ b/biology/vsearch/Makefile
@@ -1,30 +1,30 @@
 PORTNAME=		vsearch
 DISTVERSIONPREFIX=	v
-DISTVERSION=		2.21.2
+DISTVERSION=		2.22.1
 CATEGORIES=		biology
 
 MAINTAINER=	jwb@FreeBSD.org
 COMMENT=	Versatile open-source tool for metagenomics
 WWW=		https://github.com/torognes/vsearch
 
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 ONLY_FOR_ARCHS=		aarch64 amd64 powerpc64le
 ONLY_FOR_ARCHS_REASON=	Explicitly enumerated by upstream developers
 
 LIB_DEPENDS=	libsysinfo.so:devel/libsysinfo
 
 USES=		autoreconf ghostscript:build gmake localbase
 USE_GITHUB=	yes
 
 GH_ACCOUNT=	torognes
 GNU_CONFIGURE=	yes
 
 PLIST_FILES=	bin/vsearch man/man1/vsearch.1.gz
 PORTDOCS=	*
 
 OPTIONS_DEFINE=	DOCS
 OPTIONS_SUB=	yes
 
 .include <bsd.port.mk>
diff --git a/biology/vsearch/distinfo b/biology/vsearch/distinfo
index 302a7dc12ee4..e56ce336e84e 100644
--- a/biology/vsearch/distinfo
+++ b/biology/vsearch/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1663095644
-SHA256 (torognes-vsearch-v2.21.2_GH0.tar.gz) = 841361c5e2081945177f6a63e2a85674b8c2aa439ad2b81dfc44b2a6c0b4b484
-SIZE (torognes-vsearch-v2.21.2_GH0.tar.gz) = 257953
+TIMESTAMP = 1663633180
+SHA256 (torognes-vsearch-v2.22.1_GH0.tar.gz) = c62bf69e7cc3d011a12e3b522ba8c0c91fb90deea782359e9569677d0c991778
+SIZE (torognes-vsearch-v2.22.1_GH0.tar.gz) = 260920