diff --git a/sys/dev/cardbus/cardbus.c b/sys/dev/cardbus/cardbus.c
--- a/sys/dev/cardbus/cardbus.c
+++ b/sys/dev/cardbus/cardbus.c
@@ -212,6 +212,7 @@
 			DEVPRINTF((cbdev, "Warning: Bogus CIS ignored\n"));
 		pci_cfg_save(dinfo->pci.cfg.dev, &dinfo->pci, 0);
 		pci_cfg_restore(dinfo->pci.cfg.dev, &dinfo->pci);
+		pci_clear_pme(child);
 		cardbus_device_setup_regs(&dinfo->pci.cfg);
 		pci_add_resources(cbdev, child, 1, dinfo->mprefetchable);
 		pci_print_verbose(&dinfo->pci);
diff --git a/sys/dev/pci/pci.c b/sys/dev/pci/pci.c
--- a/sys/dev/pci/pci.c
+++ b/sys/dev/pci/pci.c
@@ -2933,6 +2933,24 @@
 	return (result);
 }
 
+/* Clear any active PME# and disable PME# generation. */
+void
+pci_clear_pme(device_t dev)
+{
+	struct pci_devinfo *dinfo = device_get_ivars(dev);
+	pcicfgregs *cfg = &dinfo->cfg;
+	uint16_t status;
+
+	if (cfg->pp.pp_location != 0) {
+		status = pci_read_config(dev, dinfo->cfg.pp.pp_location +
+		    PCIR_POWER_STATUS, 2);
+		status &= ~PCIM_PSTAT_PMEENABLE;
+		status |= PCIM_PSTAT_PME;
+		pci_write_config(dev, dinfo->cfg.pp.pp_location +
+		    PCIR_POWER_STATUS, status, 2);
+	}
+}
+
 /*
  * Some convenience functions for PCI device drivers.
  */
@@ -4470,6 +4488,7 @@
 	resource_list_init(&dinfo->resources);
 	pci_cfg_save(dev, dinfo, 0);
 	pci_cfg_restore(dev, dinfo);
+	pci_clear_pme(dev);
 	pci_print_verbose(dinfo);
 	pci_add_resources(bus, dev, 0, 0);
 	if (pci_enable_mps_tune)
@@ -4660,6 +4679,7 @@
 
 	dinfo = device_get_ivars(child);
 	pci_cfg_restore(child, dinfo);
+	pci_clear_pme(child);
 	if (!device_is_attached(child))
 		pci_cfg_save(child, dinfo, 1);
 
diff --git a/sys/dev/pci/pcivar.h b/sys/dev/pci/pcivar.h
--- a/sys/dev/pci/pcivar.h
+++ b/sys/dev/pci/pcivar.h
@@ -684,6 +684,7 @@
 void	pci_save_state(device_t dev);
 int	pci_set_max_read_req(device_t dev, int size);
 int	pci_power_reset(device_t dev);
+void	pci_clear_pme(device_t dev);
 uint32_t pcie_read_config(device_t dev, int reg, int width);
 void	pcie_write_config(device_t dev, int reg, uint32_t value, int width);
 uint32_t pcie_adjust_config(device_t dev, int reg, uint32_t mask,