diff --git a/sys/dev/gve/gve_main.c b/sys/dev/gve/gve_main.c
--- a/sys/dev/gve/gve_main.c
+++ b/sys/dev/gve/gve_main.c
@@ -196,6 +196,8 @@
 gve_set_mtu(if_t ifp, uint32_t new_mtu)
 {
 	struct gve_priv *priv = if_getsoftc(ifp);
+	const uint32_t max_problem_range = 8227;
+	const uint32_t min_problem_range = 7822;
 	int err;
 
 	if ((new_mtu > priv->max_mtu) || (new_mtu < ETHERMIN)) {
@@ -204,6 +206,19 @@
 		return (EINVAL);
 	}
 
+	/*
+	 * When hardware LRO is enabled in DQ mode, MTUs within the range
+	 * [7822, 8227] trigger hardware issues which cause a drastic drop
+	 * in throughput.
+	 */
+	if (!gve_is_gqi(priv) && !gve_disable_hw_lro &&
+	    new_mtu >= min_problem_range && new_mtu <= max_problem_range) {
+		device_printf(priv->dev,
+		    "Cannot set to MTU to %d within the range [%d, %d] while hardware LRO is enabled\n",
+		    new_mtu, min_problem_range, max_problem_range);
+		return (EINVAL);
+	}
+
 	err = gve_adminq_set_mtu(priv, new_mtu);
 	if (err == 0) {
 		if (bootverbose)