diff --git a/biology/fermi-lite/Makefile b/biology/fermi-lite/Makefile
--- a/biology/fermi-lite/Makefile
+++ b/biology/fermi-lite/Makefile
@@ -11,10 +11,14 @@
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
-ONLY_FOR_ARCHS=		amd64 i386
+ONLY_FOR_ARCHS=		aarch64 amd64 armv7 i386
 ONLY_FOR_ARCHS_REASON=	Use of the <emmintrin.h> header in ksw.c which is only for SSE2
 
-USES=		gmake
+armv7_BUILD_DEPENDS=	${LOCALBASE}/include/sse2neon.h:devel/sse2neon
+aarch64_BUILD_DEPENDS=	${armv7_BUILD_DEPENDS}
+BUILD_DEPENDS+=	${${ARCH}_BUILD_DEPENDS}
+
+USES=		gmake localbase
 USE_LDCONFIG=	yes
 
 USE_GITHUB=	yes
diff --git a/biology/fermi-lite/files/patch-ksw.c b/biology/fermi-lite/files/patch-ksw.c
new file mode 100644
--- /dev/null
+++ b/biology/fermi-lite/files/patch-ksw.c
@@ -0,0 +1,14 @@
+--- ksw.c.orig	2024-10-15 14:34:34 UTC
++++ ksw.c
+@@ -25,7 +25,11 @@
+ 
+ #include <stdlib.h>
+ #include <stdint.h>
++#if defined(__arm__) || defined(__aarch64__)
++#include <sse2neon.h>
++#else
+ #include <emmintrin.h>
++#endif
+ #include "ksw.h"
+ 
+ #ifdef __GNUC__