diff --git a/security/tpm2-tss/Makefile b/security/tpm2-tss/Makefile
--- a/security/tpm2-tss/Makefile
+++ b/security/tpm2-tss/Makefile
@@ -1,6 +1,5 @@
 PORTNAME=	tpm2-tss
-DISTVERSION=	3.2.0
-PORTREVISION=	1
+DISTVERSION=	4.0.1
 CATEGORIES=	security
 MASTER_SITES=	https://github.com/tpm2-software/tpm2-tss/releases/download/${DISTVERSION}/
 
@@ -10,7 +9,8 @@
 LICENSE=	BSD2CLAUSE
 
 LIB_DEPENDS=	libjson-c.so:devel/json-c \
-		libcurl.so:ftp/curl
+		libcurl.so:ftp/curl \
+		libuuid.so:misc/e2fsprogs-libuuid
 
 USES=		compiler:c11 gmake libtool pkgconfig ssl
 USE_LDCONFIG=	yes
diff --git a/security/tpm2-tss/distinfo b/security/tpm2-tss/distinfo
--- a/security/tpm2-tss/distinfo
+++ b/security/tpm2-tss/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1646512509
-SHA256 (tpm2-tss-3.2.0.tar.gz) = 48305e4144dcf6d10f3b25b7bccf0189fd2d1186feafd8cd68c6b17ecf0d7912
-SIZE (tpm2-tss-3.2.0.tar.gz) = 1629211
+TIMESTAMP = 1694301508
+SHA256 (tpm2-tss-4.0.1.tar.gz) = 532a70133910b6bd842289915b3f9423c0205c0ea009d65294ca18a74087c950
+SIZE (tpm2-tss-4.0.1.tar.gz) = 1787139
diff --git a/security/tpm2-tss/pkg-plist b/security/tpm2-tss/pkg-plist
--- a/security/tpm2-tss/pkg-plist
+++ b/security/tpm2-tss/pkg-plist
@@ -13,6 +13,7 @@
 include/tss2/tss2_esys.h
 include/tss2/tss2_fapi.h
 include/tss2/tss2_mu.h
+include/tss2/tss2_policy.h
 include/tss2/tss2_rc.h
 include/tss2/tss2_sys.h
 include/tss2/tss2_tcti.h
@@ -20,13 +21,14 @@
 include/tss2/tss2_tcti_device.h
 include/tss2/tss2_tcti_mssim.h
 include/tss2/tss2_tcti_pcap.h
+include/tss2/tss2_tcti_spi_helper.h
 include/tss2/tss2_tcti_swtpm.h
 include/tss2/tss2_tctildr.h
 include/tss2/tss2_tpm2_types.h
 lib/libtss2-esys.a
 lib/libtss2-esys.so
 lib/libtss2-esys.so.0
-lib/libtss2-esys.so.0.0.0
+lib/libtss2-esys.so.0.0.1
 lib/libtss2-fapi.a
 lib/libtss2-fapi.so
 lib/libtss2-fapi.so.1
@@ -34,15 +36,23 @@
 lib/libtss2-mu.a
 lib/libtss2-mu.so
 lib/libtss2-mu.so.0
-lib/libtss2-mu.so.0.0.0
+lib/libtss2-mu.so.0.0.1
+lib/libtss2-policy.a
+lib/libtss2-policy.so
+lib/libtss2-policy.so.0
+lib/libtss2-policy.so.0.0.0
 lib/libtss2-rc.a
 lib/libtss2-rc.so
 lib/libtss2-rc.so.0
 lib/libtss2-rc.so.0.0.0
+lib/libtss2-tcti-spi-helper.a
+lib/libtss2-tcti-spi-helper.so
+lib/libtss2-tcti-spi-helper.so.0
+lib/libtss2-tcti-spi-helper.so.0.0.0
 lib/libtss2-sys.a
 lib/libtss2-sys.so
 lib/libtss2-sys.so.1
-lib/libtss2-sys.so.1.0.0
+lib/libtss2-sys.so.1.0.1
 lib/libtss2-tcti-cmd.a
 lib/libtss2-tcti-cmd.so
 lib/libtss2-tcti-cmd.so.0
@@ -70,12 +80,14 @@
 libdata/pkgconfig/tss2-esys.pc
 libdata/pkgconfig/tss2-fapi.pc
 libdata/pkgconfig/tss2-mu.pc
+libdata/pkgconfig/tss2-policy.pc
 libdata/pkgconfig/tss2-rc.pc
 libdata/pkgconfig/tss2-sys.pc
 libdata/pkgconfig/tss2-tcti-cmd.pc
 libdata/pkgconfig/tss2-tcti-device.pc
 libdata/pkgconfig/tss2-tcti-mssim.pc
 libdata/pkgconfig/tss2-tcti-pcap.pc
+libdata/pkgconfig/tss2-tcti-spi-helper.pc
 libdata/pkgconfig/tss2-tcti-swtpm.pc
 libdata/pkgconfig/tss2-tctildr.pc
 man/man3/Tss2_TctiLdr_Finalize.3.gz