diff --git a/Mk/Uses/python.mk b/Mk/Uses/python.mk
--- a/Mk/Uses/python.mk
+++ b/Mk/Uses/python.mk
@@ -675,7 +675,6 @@
 RUN_DEPENDS+=		${PYTHON_PKGNAMEPREFIX}setuptools44>0:devel/py-setuptools44@${PY_FLAVOR}
 .    else
 BUILD_DEPENDS+=		${PYTHON_PKGNAMEPREFIX}setuptools>=63.1.0:devel/py-setuptools@${PY_FLAVOR}
-RUN_DEPENDS+=		${PYTHON_PKGNAMEPREFIX}setuptools>=63.1.0:devel/py-setuptools@${PY_FLAVOR}
 .    endif
 .  endif