diff --git a/CHANGES b/CHANGES
--- a/CHANGES
+++ b/CHANGES
@@ -10,6 +10,19 @@
 
 All ports committers are allowed to commit to this file.
 
+20220415:
+AUTHOR: amdmi3@FreeBSD.org
+
+  A new USES has been added to handle testing with pytest.
+
+    USES=           pytest
+
+  Introduces dependency on pytest and adds do-test target which calls
+  pytest with the right environment and arguments.
+
+  Additionally, PYTEST_{IGNORED,BROKEN}_TESTS knobs are provided for
+  skipping failing tests in a convenient and documented way.
+
 20220218:
 AUTHOR: jrm@FreeBSD.org
 
diff --git a/Mk/Uses/pytest.mk b/Mk/Uses/pytest.mk
new file mode 100644
--- /dev/null
+++ b/Mk/Uses/pytest.mk
@@ -0,0 +1,69 @@
+# handle testing with pytest
+#
+# Feature:	pytest
+# Usage:	USES=pytest[:4]
+#
+# It implies USES=python:test automatically if no USES=python has been
+# specified yet
+#
+# It provides the following additional variables to set by the ports:
+#
+# PYTEST_ARGS		additional args to pytest (defaults to empty).
+# PYTEST_IGNORED_TESTS	lists of `pytest -k` patterns of tests to ignore
+# 			(defaults to empty). For tests which are not
+#			expected to pass, such as ones requiring a database
+#			access.
+# PYTEST_BROKEN_TESTS	lists of `pytest -k` patterns of tests to ignore
+# 			(defaults to empty). For broken tests which require
+#			fixing.
+#
+# The following variables may be set by the user:
+#
+# PYTEST_ENABLE_IGNORED_TESTS	enable tests which are otherwise ignored by
+#				PYTEST_IGNORED_TESTS.
+# PYTEST_ENABLE_BROKEN_TESTS	enable tests which are otherwise ignored by
+#				PYTEST_BROKEN_TESTS.
+# PYTEST_ENABLE_ALL_TESTS	enable tests which are otherwise ignored by
+#				PYTEST_IGNORED_TESTS and PYTEST_BROKEN_TESTS.
+#
+# MAINTAINER: amdmi3@FreeBSD.org
+
+.if !defined(_INCLUDE_USES_PYTEST_MK)
+_INCLUDE_USES_PYTEST_MK=	yes
+
+.  if !${USES:Mpython*}
+python_ARGS=	test
+.    include "${USESDIR}/python.mk"
+.  endif
+
+.  if empty(pytest_ARGS)
+TEST_DEPENDS+=		${PYTHON_PKGNAMEPREFIX}pytest>=0:devel/py-pytest@${PY_FLAVOR}
+.  elif ${pytest_ARGS} == "4"
+TEST_DEPENDS+=		${PYTHON_PKGNAMEPREFIX}pytest4>=0:devel/py-pytest4@${PY_FLAVOR}
+.  else
+IGNORE=	Incorrect 'USES+=pytest:${pytest_ARGS}' expecting 'USES+=pytest[:4]'
+.  endif
+
+PYTEST_IGNORED_TESTS?=	# empty
+PYTEST_BROKEN_TESTS?=	# empty
+PYTEST_ARGS?=		# empty
+
+_PYTEST_ALL_IGNORED_TESTS?=	# empty
+.  if !defined(PYTEST_ENABLE_IGNORED_TESTS) && !defined(PYTEST_ENABLE_ALL_TESTS)
+_PYTEST_ALL_IGNORED_TESTS+=	${PYTEST_IGNORED_TESTS}
+.  endif
+.  if !defined(PYTEST_ENABLE_BROKEN_TESTS) && !defined(PYTEST_ENABLE_ALL_TESTS)
+_PYTEST_ALL_IGNORED_TESTS+=	${PYTEST_BROKEN_TESTS}
+.  endif
+
+_PYTEST_FILTER_EXPRESSION=	${_PYTEST_ALL_IGNORED_TESTS:C/^(.)/and not \1/:tW:C/^and //}
+
+.  if !target(do-test)
+do-test:
+	@cd ${TEST_WRKSRC} && ${SETENV} ${TEST_ENV} ${PYTHON_CMD} -m pytest \
+		-k '${_PYTEST_FILTER_EXPRESSION}' \
+		-v -rs -o addopts= \
+		${PYTEST_ARGS}
+.  endif
+
+.endif